Methyl (2s)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetate CAS 1821776-64-0

Purity 97%+In StockPharmaceutical Standards
CAS No.1821776-64-0
Molecular FormulaC10H9F3O3
Molecular Weight234.17 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

Methyl (2s)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetate CAS 1821776-64-0 chemical structure

Description

The occurrence of Methyl (2s)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetate is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

Methyl (2s)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetate (CAS 1821776-64-0), molecular formula C10H9F3O3 and molecular weight 234.17 g/mol, is a CATO reference standard with documented purity and traceability.

Methyl (2s)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetate (C10H9F3O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), Methyl (2s)-2-hydroxy-2-[3-(trifluoromethyl)phenyl]acetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC10H9F3O3
Molecular Weight234.17 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, low volatility)
Purity97%+
StorageStore in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, ethanol, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)5.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1995
Halogen ContentF-containing

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