3-Chloro-4-(piperazin-1-yl)benzonitrile CAS 182181-32-4
| CAS No. | 182181-32-4 |
| Molecular Formula | C11H12ClN3 |
| Molecular Weight | 221.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3-Chloro-4-(piperazin-1-yl)benzonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 3-Chloro-4-(piperazin-1-yl)benzonitrile (CAS 182181-32-4), a certified reference material (molecular formula C11H12ClN3, MW 221.69 g/mol) for analytical method development and quality control.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, 3-Chloro-4-(piperazin-1-yl)benzonitrile is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 221.69 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C11H12ClN3 |
| Molecular Weight | 221.69 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 2-(4-Chloro-3,5-dimethyl-1h-pyrazol-1-yl)aniline (CAS 1006467-22-6)
- 1-(3-Chloro-2-methylphenyl)-3-methyl-1H-pyrazol-5-amine (CAS 1020703-64-3)
- 5-Chloro-2-(pyrrolidin-2-yl)-1h-1,3-benzodiazole (CAS 1035841-23-6)
- 3-Chloro-5-phenyl-4-(propan-2-yl)-4h-1,2,4-triazole (CAS 1087792-43-5)
- 2-Chloro-6-(piperazin-1-yl)benzonitrile (CAS 1093092-08-0)
- 4-Chloro-3-(piperazin-1-yl)benzonitrile (CAS 1121600-41-6)
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Recommended Standards
- 2-(5-(4-Chlorophenyl)-1H-pyrazol-1-yl)ethanamine (CAS 1710302-45-6)
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- 1-Chloro-8,9,10,11-tetrahydro-7H-cyclohepta[3,4]pyrazolo[1,5-a]pyrazine (CAS 1707735-01-0)
- (4-Chlorophenyl)(1-methyl-1H-imidazol-2-yl)methylamine (CAS 871217-40-2)
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- Methyl 2-(aminomethyl)-4-methylthiazole-5-carboxylate (CAS 1017393-27-9)
- 3-(3-Methoxyphenyl)-5-(4-nitrophenyl)-4-phenyl-4H-1,2,4-triazole (CAS 62507-58-8)
- N-Isopropylbenzamide (CAS 5440-69-7)
- 5-(Methylsulfinyl)-1H-indole (CAS 152879-72-6)
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