4,4-Difluoro-5-oxopyrrolidine-2-carboxylic acid CAS 1822546-72-4
| CAS No. | 1822546-72-4 |
| Molecular Formula | C5H5F2NO3 |
| Molecular Weight | 165.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4,4-Difluoro-5-oxopyrrolidine-2-carboxylic acid is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4,4-Difluoro-5-oxopyrrolidine-2-carboxylic acid (CAS 1822546-72-4), a certified reference material (molecular formula C5H5F2NO3, MW 165.09 g/mol) for analytical method development and quality control.
The molecular framework of 4,4-Difluoro-5-oxopyrrolidine-2-carboxylic acid (C5H5F2NO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4,4-Difluoro-5-oxopyrrolidine-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5F2NO3 |
| Molecular Weight | 165.09 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
- 4,4-Difluoro-5-oxopyrrolidine-3-carboxylic acid (CAS 1784824-78-7)
- 3,5-Difluoro-4-(difluoromethyl)pyridine (CAS 1804935-03-2)
- (S)-4,4-difluoro-5-oxopyrrolidine-2-carboxylic acid (CAS 1932456-62-6)
- (R)-4,4-difluoro-5-oxopyrrolidine-2-carboxylic acid (CAS 2165595-41-3)
- 2,2-Difluoro-N-methoxy-N-methylcyclopropane-1-carboxamide (CAS 1202774-49-9)
- 3,3-Difluoro-4-(hydroxymethyl)piperidin-2-one (CAS 1258639-19-8)
- 3,3-Difluoro-4-piperidinecarboxylic acid (CAS 1303974-04-0)
- (S)-4,4-difluoro-1-methylpyrrolidine-2-carboxylic acid (CAS 1305325-21-6)
Recommended Standards
- 3-(Difluoromethyl)-2,5-difluoropyridine (CAS 1806773-16-9)
- 5-(Difluoromethyl)-2,3-difluoropyridine (CAS 1804659-36-6)
- 2,3,4,6-Tetrafluoroaniline (CAS 363-73-5)
- 2,3,5,6-Tetrafluoroaniline (CAS 700-17-4)
- N-(cyclohexylmethyl)diisopropylamino (CAS 80934-61-8)
- 2-(2,3-Dichlorophenyl)-4-methyl-5-(1H-pyrazol-5-yl)thiazole (CAS 1397216-94-2)
- 2,6-Bis(3-methyl-1H-pyrazol-1-yl)pyrazine (CAS 612820-39-0)
- (5-(Benzyloxy)pyridin-3-yl)methanamine (CAS 1044919-30-3)
- 3-(2,2-Difluoroethoxy)-1-isopropyl-1H-pyrazol-4-amine (CAS 1431968-11-4)
- 2-(2-Cyclopropylpyrimidin-4-yl)ethan-1-amine (CAS 1340249-35-5)
- Methyl 1-(sec-butyl)-4-iodo-1h-pyrazole-3-carboxylate (CAS 1354705-62-6)
- Virginiamycin M1 (CAS 21411-53-0)
- ((1S,4r)-4-propylcyclohexyl)methyl methanesulfonate (CAS 2071203-42-2)
- Semaglutide Main Chain P29 (CAS 1169630-82-3)
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