Cefadroxil Sulfoxide(RS) CAS 182290-77-3
| CAS No. | 182290-77-3 |
| Molecular Formula | C16H17N3O6S |
| Molecular Weight | 379.39 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cefadroxil Sulfoxide(RS).
CATO supplies Cefadroxil Sulfoxide(RS) (CAS 182290-77-3), a pharmacopoeial impurity reference standard (molecular formula C16H17N3O6S, MW 379.39 g/mol) used for the identification and quantification of trace impurities in APIs.
Cefadroxil Sulfoxide(RS) (C16H17N3O6S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H17N3O6S |
| Molecular Weight | 379.39 g/mol |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Cefadroxil Standards
- R-Cefadroxil Sulfoxide (CAS CATO-C4X-122415)
- S-Cefadroxil Sulfoxide (CAS CATO-C4X-122416)
- Cefadroxil Impurity 25 (CAS CATO-C4X-122425)
- Cefadroxil Ethyl Homolog (CAS 2243976-70-5)
- Cefadroxil Impurity 38 (CAS CATO-C4X-122438)
- Cefadroxil Impurity 46 (CAS CATO-C4X-122446)
- Cefadroxil Impurity 19 (CAS CATO-C4X-122419)
- Cefadroxil EP Impurity D (CAS 144790-28-3)
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