3-(4-(Hydroxymethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-6-(trifluoromethyl)pyrimidin-4(3H)-one CAS 1823182-38-2
| CAS No. | 1823182-38-2 |
| Molecular Formula | C11H8F6N4O2 |
| Molecular Weight | 342.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(4-(Hydroxymethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-6-(trifluoromethyl)pyrimidin-4(3H)-one.
CATO supplies 3-(4-(Hydroxymethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 1823182-38-2), a certified reference material (molecular formula C11H8F6N4O2, MW 342.20 g/mol) for analytical method development and quality control.
3-(4-(Hydroxymethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-6-(trifluoromethyl)pyrimidin-4(3H)-one (C11H8F6N4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(4-(Hydroxymethyl)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-6-(trifluoromethyl)pyrimidin-4(3H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8F6N4O2 |
| Molecular Weight | 342.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Hydroxymethyl Standards
- (R)-5-(Hydroxymethyl)-3-(2,3,5-trifluoro-4-(4-oxo-3,4-dihydropyridin-1(2H)-yl)phenyl)oxazolidin-2-one (CAS 1112968-16-7)
- 2-(hydroxymethyl)-6-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxane-3,4,5-triol (CAS 1174299-27-4)
- N-[5-(Hydroxymethyl)-2-phenyl-1,3-dioxan-5-yl]-carbamic Acid Benzyl Ester (CAS 1125824-87-4)
- (Z)-5-(Hydroxymethyl)-3-((4-(morpholinomethyl)-1H-pyrrol-2-yl)methylene)indolin-2-one (CAS 1265965-20-5)
- 5-(Hydroxymethyl)-4-(((2-(5-methoxy-1H-indol-3-yl)ethyl)imino)methyl)-2-methylpyridin-3-ol (CAS 98497-90-6)
- (2-(Hydroxymethyl)piperidin-1-yl)(4-iodophenyl)methanone (CAS 1156334-52-9)
- (4-(Hydroxymethyl)piperidin-1-yl)(2-iodophenyl)methanone (CAS 1178917-65-1)
- 4-((4-((4-(Hydroxymethyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile (CAS 823786-21-6)
Recommended Standards
- (E)-4,4'-(Diazene-1,2-diyl)bis(3,5-difluorobenzoic acid) (CAS 1661863-04-2)
- (Z)-1-(3,4-dichlorophenyl)-2-(hydroxyimino)-2-(2-(methylthio)pyrimidin-4-yl)ethan-1-one (CAS 939761-42-9)
- 3-[4-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyrazol-1-ylmethyl]-benzoic acid methyl ester (CAS 1404431-51-1)
- 1-(Furan-2-ylmethyl)-3-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (CAS 874299-16-8)
- Ethyl 5-chloro-1-(2-fluorophenyl)-1H-pyrazole-4-carboxylate (CAS 1245279-25-7)
- tert-butyl N-(5-amino-5,6,7,8-tetrahydronaphthalen-2-yl)carbamate (CAS 1262407-95-3)
- 5-Methyl-2-(pyridin-3-yl)-1,3-thiazol-4-yl 2-chloro-4-methanesulfonylbenzoate (CAS 338399-02-3)
- N1-Cyclohexyl-N2-(2,4-difluorophenyl)oxalamide (CAS 898356-54-2)
- N-[3-(5-Amino-1,3,4-thiadiazol-2-yl)propyl]-4-methylbenzenesulfonamide (CAS 1199216-00-6)
- N-Benzyl-2-(5-(thiophen-2-yl)isoxazol-3-yl)acetamide (CAS 946227-71-0)
- 25940-35-6 3-pyrazolo[1,5-a]pyrimidinecarboxylic acid A818097 pyrazolo[1,5-a]pyrimidine-3-carboxylic acid (CAS 25940-35-6)
- 4-Methanesulfonyl-2-(trifluoromethyl)benzoic acid (CAS 118939-17-6)
- 5-Iodo-2-(pyrrolidin-2-yl)pyrimidine hydrochloride (CAS 1817679-15-4)
- Tirzepatide Impurity 9 (CAS CATO-C4X-32409)
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