5-Fluoro-2-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-4-(methylthio)pyrimidine CAS 1823182-78-0
| CAS No. | 1823182-78-0 |
| Molecular Formula | C11H6F5N3S |
| Molecular Weight | 307.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 5-Fluoro-2-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-4-(methylthio)pyrimidine (C11H6F5N3S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies 5-Fluoro-2-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-4-(methylthio)pyrimidine (CAS 1823182-78-0), a certified reference material (molecular formula C11H6F5N3S, MW 307.24 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H6F5N3S |
| Molecular Weight | 307.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Fluoro Standards
- 4-Fluoro-3-[(trifluoromethyl)sulfonyl]benzenesulfonamide (CAS 1027345-08-9)
- 5-Fluoro-2-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-6-methylpyrimidine-4(3H)-thione (CAS 1823183-53-4)
- N-(2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-2-methylpropan-2-amine (CAS 1256360-52-7)
- N-(2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)butan-1-amine (CAS 2377610-92-7)
- N-(4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)butan-1-amine (CAS 2096329-98-3)
- N-(4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-2-methylpropan-2-amine (CAS 2096341-84-1)
- 4-(3-Fluoro-4-methylphenyl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide (CAS 1325303-39-6)
- 4-(4-Fluoro-3-methylphenyl)-2H-pyrido[2,3-e][1,2,4]thiadiazin-3(4H)-one 1,1-dioxide (CAS 1325305-83-6)
Recommended Standards
- Cidofovir USP Related Compound A (CAS 1312776-50-3)
- Diethyl 2-{[(trifluoromethyl)sulfonyl]amino}malonate (CAS 1155138-70-7)
- 4-Acetamido-[1,1'-biphenyl]-3-yl dihydrogen phosphate (CAS 77273-71-3)
- 4-[1-Methyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl]morpholine (CAS 1046832-14-7)
- (R)-2-(2-(1H-Indol-3-yl)acetamido)-3-mercaptopropanoic acid (CAS 57105-44-9)
- (2-Propoxyphenyl)methanamine (CAS 37806-31-8)
- 3-methylthiolan-3-ol (CAS 144877-33-8)
- 2-Cyano-3-(2,5-dimethoxyphenyl)-N-(2-methoxyphenyl)propanamide (CAS 1261016-16-3)
- n-(3-Amino-4-fluorophenyl)-2-iodobenzamide (CAS 926256-47-5)
- 1,3,3-Trimethyl-7-oxabicyclo[4.1.0]heptane-2-carbonitrile (CAS 264279-20-1)
- Nevanimibe Hydrochloride (CAS 133825-81-7)
- 3-Amino-2-chloropyridine-5-boronic Acid Pinacol Ester (CAS 1073354-96-7)
- 1-(5-(Benzyloxy)-2,4-dichlorophenyl)-5-(2,6-difluorophenyl)-1H-tetrazole (CAS 338961-50-5)
- Calcitonin C-Terminal Flanking Peptide (human) XTFA (CAS 85916-47-8（free base）)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com