Methyl-(6-trifluoromethyl-pyrimidin-4-yl)-amine CAS 1823585-68-7
| CAS No. | 1823585-68-7 |
| Molecular Formula | C6H6F3N3 |
| Molecular Weight | 177.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Methyl-(6-trifluoromethyl-pyrimidin-4-yl)-amine (C6H6F3N3) is characterized by a nitrile group, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Methyl-(6-trifluoromethyl-pyrimidin-4-yl)-amine (CAS 1823585-68-7) is a high-purity analytical reference standard with the molecular formula C6H6F3N3 and a molecular weight of 177.13 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Methyl-(6-trifluoromethyl-pyrimidin-4-yl)-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6F3N3 |
| Molecular Weight | 177.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Methyl Standards
- 5-(Trifluoromethyl)pyrazine-2-methanamine (CAS 1060812-71-6)
- 3-(Trifluoromethyl)pyridine-2,6-diamine (CAS 1063697-16-4)
- 3-(Trifluoromethyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole (CAS 1073556-30-5)
- 5-(Trifluoromethyl)pyridine-2,3-diamine (CAS 107867-51-6)
- 6-(Trifluoromethyl)pyrazine-2-methanamine (CAS 1196151-50-4)
- (3-(Trifluoromethyl)pyrazin-2-yl)methanamine (CAS 1197235-85-0)
- (6-(Trifluoromethyl)pyridazin-3-yl)methanamine (CAS 1211580-33-4)
- 3-(Trifluoromethyl)pyridine-2,4-diamine (CAS 1227563-89-4)
Recommended Standards
- 6-(Difluoromethyl)-3-fluoropyridine-2,4-diamine (CAS 1806811-74-4)
- 2,2,2-Trifluoro-1-(pyrimidin-4-yl)ethan-1-amine (CAS 1936287-20-5)
- 5-(Difluoromethyl)-3-fluoropyridine-2,4-diamine (CAS 1806804-44-3)
- (2-(Trifluoromethyl)pyrimidin-4-yl)methanamine (CAS 916303-80-5)
- (R)-5-Oxiranylmethoxyquinoline (CAS 145679-40-9)
- 5-Methoxy-N-(piperidin-4-yl)pyridin-2-amine trihydrochloride (CAS 1779124-12-7)
- 4-(4-Acetylpiperazin-1-yl)-2-fluorobenzaldehyde (CAS 1445902-92-0)
- TIPPP purified ion m/z 410 (CAS 28109-00-4)
- Tert-butyl (5-methylbenzo[d]isoxazol-3-yl)carbamate (CAS 1344692-94-9)
- (1-Methyl-9H-pyrido[3,4-b]indol-3-yl)methanamine (CAS 63885-91-6)
- (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(5-chloro-1H-indol-3-yl)propanoic acid (CAS 1257856-10-2)
- Tert-butyl 4-fluoro-6-hydroxy-1H-indazole-1-carboxylate (CAS 1253789-61-5)
- 4-Oxo-4-(4-(3-phenylallyl)piperazin-1-yl)but-2-enoic acid (CAS 550299-54-2)
- Semaglutide impurity 31 (CAS CATO-C4X-222631)
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