Tert-butyl 4-(2,3-dihydroxypropyl)-3,3-difluoropyrrolidine-1-carboxylate CAS 1823808-90-7
| CAS No. | 1823808-90-7 |
| Molecular Formula | C12H21F2NO4 |
| Molecular Weight | 281.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tert-butyl 4-(2,3-dihydroxypropyl)-3,3-difluoropyrrolidine-1-carboxylate.
Tert-butyl 4-(2,3-dihydroxypropyl)-3,3-difluoropyrrolidine-1-carboxylate (CAS 1823808-90-7), molecular formula C12H21F2NO4 and molecular weight 281.30 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Tert-butyl 4-(2,3-dihydroxypropyl)-3,3-difluoropyrrolidine-1-carboxylate (C12H21F2NO4) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H21F2NO4 |
| Molecular Weight | 281.30 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 5-(tert-Butyl) 3-ethyl 4,6-dihydro-5H-furo[2,3-c]pyrrole-3,5-dicarboxylate (CAS 1823271-85-7)
- 2-{[(tert-butoxy)carbonyl](3-methoxyphenyl)amino}acetic acid (CAS 1909318-57-5)
- Aminooxy-PEG4-acid (CAS 1807537-38-7)
- Tert-butyl (2-(4-hydroxy-3-(hydroxymethyl)phenyl)-2-oxoethyl)carbamate (CAS 1942890-99-4)
- 2-Morpholinothiazole-5-carboxylic acid (CAS 332345-29-6)
- Ethyl Isovalerate (CAS 108-64-5)
- N-(4-Chloro-2-methylphenyl)cyclopropanecarboxamide (CAS 23742-27-0)
- (R)-(-)-4,12-Bis(di(3,5-xylyl)phosphino)-[2.2]-paracyclophane (CAS 325168-89-6)
- Butyl 2-((2,6-dimethylphenyl)carbamoyl)piperidine-1-carboxylate (CAS 2488656-58-0)
- Methyl (1R,3R)-3-(aminomethyl)-3-fluorocyclopentane-1-carboxylate (CAS 2361608-79-7)
- 2-Bromo-3-(cyclobutylmethoxy)pyridine (CAS 1465670-64-7)
- 3-(Oxolan-3-yl)azetidine (CAS 1334148-09-2)
- Ruthenium, hydro[(1,2,3,4,5-η)-6-oxo-2,4-cyclohexadien-1-yl]bis(triphenylphosphine)- (CAS 61817-37-6)
- Compstatin control peptide (CAS 301544-78-5)
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