2-Hydroxy-6-methyl-4-(trifluoromethyl)quinoline CAS 1828-96-2
| CAS No. | 1828-96-2 |
| Molecular Formula | C11H8F3NO |
| Molecular Weight | 227.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Hydroxy-6-methyl-4-(trifluoromethyl)quinoline (CAS 1828-96-2), molecular formula C11H8F3NO and molecular weight 227.18 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Hydroxy-6-methyl-4-(trifluoromethyl)quinoline (C11H8F3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-Hydroxy-6-methyl-4-(trifluoromethyl)quinoline under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H8F3NO |
| Molecular Weight | 227.18 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Hydroxy Standards
- 4-Hydroxy-6-methyl-2-(trifluoromethyl)quinoline (CAS 1701-20-8)
- rac 3-Hydroxy Kynurenine-13C2,15N Hydrochloride Salt (CAS 1391051-70-9)
- 2-(4-Hydroxy-3-methoxy-5-nitrophenyl)acetic acid (CAS 88516-84-1)
- 2-Hydroxy-2-(4-methoxy-3-nitrophenyl)acetic acid (CAS 90564-43-5)
- 3-Hydroxy-2,4-dimethoxy-6-nitrobenzaldehyde (CAS 886504-01-4)
- Methyl 2-hydroxy-4-methoxy-5-nitrobenzoate (CAS 723284-34-2)
- Methyl 2-Hydroxy-5-methoxy-3-nitrobenzoate (CAS 2888-09-7)
- Methyl 3-hydroxy-4-methoxy-2-nitrobenzoate (CAS 90564-40-2)
Recommended Standards
- 4'-(Trifluoromethyl)spiro[cyclopropane-1,3'-indolin]-2'-one (CAS 1822816-46-5)
- 3-Methyl-6-(trifluoromethyl)-1(2H)-isoquinolinone (CAS 1889216-58-3)
- 1-[4-(Trifluoromethoxy)phenyl]cyclopropanecarbonitrile (CAS 173859-39-7)
- (2-(Trifluoromethyl)quinolin-4-yl)methanol (CAS 362469-45-2)
- trans-2-(Methylamino)cyclohexanol Hydrochloride (CAS 260392-65-2)
- 3-Bromo-5-(3-chloro-phenyl)-pyridine (CAS 675590-26-8)
- 4-(4-Isocyanatophenyl)-2-methyl-1,3-thiazole (CAS 857283-94-4)
- 5-(5-Chloro-2-methoxyphenyl)-4-ethyl-4H-1,2,4-triazole-3-thiol (CAS 369394-90-1)
- 1-Cyclopropyl-7-(3,5-dimethylpiperazin-1-yl)-6-fluoro-4-oxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylic acid (CAS 144634-02-6)
- 5,8-Dimethoxy-4-methylquinolin-2-ol (CAS 23947-41-3)
- 5-Bromo-2-(1-(trifluoromethyl)cyclopropyl)pyridine (CAS 1431616-44-2)
- (1,5-Dimethyl-1H-1,2,4-triazol-3-yl)(3-methoxyphenyl)methanamine (CAS 1708080-40-3)
- [4-(2,6-dimethylmorpholine-4-carbonyl)phenyl]methanamine hydrochloride (CAS 1210032-03-3)
- D-Lys16-Tirzepatide (CAS CATO-CPTD788918)
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