4-Fluorobenzoyl isocyanate CAS 18354-35-3
| CAS No. | 18354-35-3 |
| Molecular Formula | C8H4FNO2 |
| Molecular Weight | 165.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Fluorobenzoyl isocyanate.
CATO supplies 4-Fluorobenzoyl isocyanate (CAS 18354-35-3), a certified reference material (molecular formula C8H4FNO2, MW 165.12 g/mol) for analytical method development and quality control.
4-Fluorobenzoyl isocyanate (C8H4FNO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4FNO2 |
| Molecular Weight | 165.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluorobenzoyl Standards
- 2-Fluorobenzoyl isocyanate (CAS 62869-34-5)
- 3-Fluorobenzoyl isocyanate (CAS 78469-21-3)
- 2-(4-Fluorobenzoyl)oxirane (CAS 688348-76-7)
- 4-Fluorobenzoyl-d4 Chloride (CAS 1071809-52-3)
- 3-Fluorobenzoyl Chloride (CAS 1711-07-5)
- 1-(4-Fluorobenzoyl)cyclopropan-1-amine (CAS 1017487-17-0)
- 3-(4-Fluorobenzoyl)azetidine (CAS 149452-32-4)
- 2-Fluorobenzoyl cyanide (CAS 80277-41-4)
Recommended Standards
- 5-Ethynyl-2-fluoronicotinic acid (CAS 1824168-20-8)
- (5-(Trifluoromethyl)-1H-imidazol-2-yl)methanamine (CAS 944898-11-7)
- 6-Fluorobenzo[d]isoxazole-3-carbaldehyde (CAS 1824114-20-6)
- 1-(2,2,2-Trifluoroethyl)-1H-pyrazol-5-amine (CAS 899899-13-9)
- (S)-3-((tert-butoxycarbonyl)amino)-2-(2-(trifluoromethyl)benzyl)propanoic acid (CAS 1260614-42-3)
- 5-Bromo-2-ethyl-1,3-thiazole Hydrochloride (CAS 1609406-77-0)
- 2-(1H-pyrazol-3-yl)acetamide (CAS 626605-59-2)
- 2-(2-(Sec-butyl)phenoxy)butanoic acid (CAS 915921-89-0)
- N-Benzyl-4-fluoro-N-methylbenzylamine (CAS 404-50-2)
- 4-(3-Aminopropyl)-2-chloropyridin-3-ol (CAS 1393557-02-2)
- 2-(Cyclopropylmethoxy)-3-fluoroaniline (CAS 1369809-67-5)
- Methyl 4,4-dimethyl-2-(methylamino)pentanoate (CAS 1342689-28-4)
- 2-(2-Methylindolizin-3-yl)ethan-1-amine (CAS 70403-45-1)
- [3,5 Diiodo-Tyr7] Peptide T (CAS 128551-40-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com