3,4-Dichloroisothiazole-5-carboxylic acid CAS 18480-53-0
| CAS No. | 18480-53-0 |
| Molecular Formula | C4HCl2NO2S |
| Molecular Weight | 198.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 3,4-Dichloroisothiazole-5-carboxylic acid (CAS 18480-53-0), a certified reference material (molecular formula C4HCl2NO2S, MW 198.03 g/mol) for analytical method development and quality control.
Structurally, 3,4-Dichloroisothiazole-5-carboxylic acid (C4HCl2NO2S) contains an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 198.03 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3,4-Dichloroisothiazole-5-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C4HCl2NO2S |
| Molecular Weight | 198.03 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Dichloroisothiazole Standards
- 4,5-Dichloroisothiazole-3-carboxylic acid (CAS 131947-13-2)
- 3,5-Dichloroisothiazole-4-carboxylic acid (CAS 3889-59-6)
- 3,4-Dichloroisothiazole-5-carboxylic acid amide (CAS 18480-55-2)
- Methyl 4,5-dichloroisothiazole-3-carboxylate (CAS 166668-76-4)
- Methyl 3,4-dichloroisothiazole-5-carboxylate (CAS 352010-56-1)
- 3,4-Dichloroisothiazole-5-carbaldehyde (CAS 1161865-89-9)
- 3,4-Dichloroisothiazole-5-carbonitrile (CAS 18480-52-9)
- 3,5-Dichloroisothiazole-4-carbonitrile (CAS 2120-82-3)
Recommended Standards
- 593-04-4 Boron trifluoride butyl ether Boron trifluoride butyl etherate Boron trifluoride dibutyl etherate Dibutyl ether-boron trifluoride Trifluoroboron dibutyl etherate (CAS 593-04-4)
- Potassium Ferrate (CAS 39469-86-8)
- Biphenyl-2-boronic Acid (CAS 4688-76-0)
- 4,5-dichloro-1-methyl-1H-pyrrole-2-carboxylic acid (CAS 106116-22-7)
- 4-Methylumbelliferyl Palmitate (CAS 17695-48-6)
- Triglyme-d6 (CAS 1219192-16-1)
- Methyl Thioglycolate (CAS 2365-48-2)
- 4-Hydroxy-2,5-dimethoxybenzaldehyde (CAS 80749-72-0)
- S-(2-(3-((2R)-4-(((((((2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl)methoxy)(hydroxy)phosphoryl)oxy)(hydroxy)phosphoryl)oxy)-2-hydroxy-3,3-dimethylbutanamido)propanamido)ethyl) methanethioate (CAS 13131-49-2)
- 3-tert-Butyl-5-(chloromethyl)isoxazole (CAS 69602-60-4)
- 5-({4-[(3-Chlorobenzyl)oxy]phenyl}methylene)-1,3-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione (CAS 477862-22-9)
- N,N-dipropylpiperidin-4-amine dihydrochloride (CAS 1220037-98-8)
- Ethyl 4-(2-naphthoyl)isoxazole-3-carboxylate (CAS 952182-79-5)
- Semaglutide Impurity 144 (CAS 394210-59-4)
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