6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one CAS 185039-46-7
| CAS No. | 185039-46-7 |
| Molecular Formula | C15H11Cl2N3OS |
| Molecular Weight | 352.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one.
6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one (CAS 185039-46-7), molecular formula C15H11Cl2N3OS and molecular weight 352.24 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution, 6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 352.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-(2,6-Dichlorophenyl)-8-methyl-2-(methylthio)pyrido[2,3-d]pyrimidin-7(8H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H11Cl2N3OS |
| Molecular Weight | 352.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Dichlorophenyl Standards
- 4-{2-[(2,3-dichlorophenyl)amino]-4-methyl-1,3-thiazol-5-yl}pyrimidin-2-amine (CAS 1823183-32-9)
- (2Z)-3-(2,6-Dichlorophenyl)-2-(4-methylbenzenesulfonyl)prop-2-enenitrile (CAS 811826-50-3)
- 1-((2,5-Dichlorophenyl)sulfonyl)piperidine-4-carbohydrazide (CAS 309278-23-7)
- 4-(2,4-Dichlorophenyl)-2-phenylthiomorpholine-3,5-dione (CAS 339109-38-5)
- 4-(3,4-Dichlorophenyl)-5-(4-methoxyphenyl)-4H-1,2,4-triazole-3-thiol (CAS 438031-65-3)
- 1-((2,6-Dichlorophenyl)sulfonamido)cyclohexane-1-carboxylic acid (CAS 885268-92-8)
- 3-(3,4-Dichlorophenyl)-3-(1,1-dioxidothiomorpholino)propanoic acid (CAS 861209-44-1)
- 1-(3,4-Dichlorophenyl)-3-methylbenzo[4,5]imidazo[1,2-a]pyridine-4-carbonitrile (CAS 730949-88-9)
Recommended Standards
- N-(4-Ethylpyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (CAS 1418307-36-4)
- (Pentafluorophenyl)diphenylphosphine (CAS 5525-95-1)
- 4-Bromo-N-(2-methoxyethyl)-3-propoxybenzenesulfonamide (CAS 1246822-97-8)
- N-(4-((3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)amino)phenyl)acetamide (CAS 1201644-31-6)
- N-(4-((4-bromophenyl)sulfonyl)phenyl)-3-chlorobenzamide (CAS 339031-54-8)
- (5-fluoro-2-hydroxyphenyl)(1-phenyl-1H-pyrazol-4-yl)methanone phenylhydrazone (CAS 1006492-56-3)
- 2-Chloro-n-(1-cyano-4-methylcyclohexyl)-n-methylpropanamide (CAS 1354950-39-2)
- 3-(2-Chloro-6-fluorophenyl)-4-(4-fluorobenzoyl)-1-methylpyrrolidine (CAS 478043-70-8)
- 3-Benzyl-1-isopropyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carbothioamide (CAS 175203-49-3)
- 8-Bromoimidazo[1,2-a]pyridine-3-carboxylic acid (CAS 1159831-04-5)
- tert-Butyl (S)-3-(cyanomethyl)piperazine-1-carboxylate (CAS 1589082-06-3)
- 4-Hexylbenzyl Chloride (CAS 58999-67-0)
- tert-Butyl (1-cyano-2-methylpropyl)carbamate (CAS 130457-35-1)
- Semaglutide Impurity 162 (x TFA Salt) (CAS CATO-C4X-2226162)
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