spiro[indane-2,4'-piperidine]-1-one hydrochloride CAS 185525-49-9
| CAS No. | 185525-49-9 |
| Molecular Formula | C13H21NO |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of spiro[indane-2,4'-piperidine]-1-one hydrochloride is closely related to an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
spiro[indane-2,4'-piperidine]-1-one hydrochloride (CAS 185525-49-9), molecular formula C13H21NOHCl and molecular weight 243.78 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of spiro[indane-2,4'-piperidine]-1-one hydrochloride (C13H21NOHCl) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H21NO HCl |
| Molecular Weight | 243.78 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related spiro Standards
- 1h-Spiro[furo[3,4-c]pyridine-3,4'-piperidine] dihydrochloride (CAS 1017599-04-0)
- SPIRO[IMIDAZOLIDINE-4,1'-INDENE]-2,5-DIONE (CAS 102325-53-1)
- Spiro[adamantane-2,3'-indole]-2'-amine hydrochloride (CAS 1029986-95-5)
- 1'H-Spiro[piperidine-4,4'-quinolin]-2'(3'H)-one hydrochloride (CAS 1032143-27-3)
- spiro[7H-furo[3,4-b]pyridine-5,4'-piperidine] (CAS 1036408-86-2)
- Spiro[piperidine-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one hydrochloride (CAS 1038866-43-1)
- Spiro[piperidine-4,4'-pyrido[2,3-d][1,3]oxazin]-2'(1'H)-one hydrochloride (CAS 1038866-44-2)
- Spiro[cyclopentane-1,1'-indene] (CAS 10408-80-7)
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- Semaglutide impurity 41 (CAS CATO-C4X-222641)
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