2-Chloro-1,5-difluoro-3-methoxybenzene CAS 18627-23-1
| CAS No. | 18627-23-1 |
| Molecular Formula | C7H5ClF2O |
| Molecular Weight | 178.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-1,5-difluoro-3-methoxybenzene.
2-Chloro-1,5-difluoro-3-methoxybenzene (CAS 18627-23-1) is a high-purity analytical reference standard with the molecular formula C7H5ClF2O and a molecular weight of 178.56 g/mol.
Structurally, 2-Chloro-1,5-difluoro-3-methoxybenzene (C7H5ClF2O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 178.56 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-1,5-difluoro-3-methoxybenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5ClF2O |
| Molecular Weight | 178.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-Chloro-2-(difluoromethoxy)benzene (CAS 119558-77-9)
- 1-Chloro-3-(difluoromethoxy)benzene (CAS 1214350-86-3)
- (3-Chloro-4,5-difluorophenyl)methanol (CAS 1260790-50-8)
- 2-Chloro-6-(difluoromethyl)phenol (CAS 1261440-82-7)
- 2-Chloro-1,3-difluoro-4-methoxybenzene (CAS 1261472-07-4)
- 3-Chloro-2-(difluoromethyl)phenol (CAS 1261479-57-5)
- 1-Chloro-4,5-difluoro-2-methoxybenzene (CAS 1261598-22-4)
- 1-Chloro-2,4-difluoro-5-methoxybenzene (CAS 1261628-93-6)
Recommended Standards
- 4-Chloro-2,3-difluorobenzyl alcohol (CAS 1805647-55-5)
- (3-chloro-2,4-difluoro-phenyl)methanol (CAS 886501-09-3)
- 5-Chloro-1,2-difluoro-3-methoxybenzene (CAS 1804875-58-8)
- (3-Chloro-2,5-difluorophenyl)methanol (CAS 67640-34-0)
- 2-(4,6-Bis(2,4-dimethylphenyl)-1,3,5-triazin-2-yl)-5-((6-methylheptyl)oxy)phenol (CAS 137759-38-7)
- 3-((Trifluoromethyl)thio)picolinic acid (CAS 1204234-50-3)
- 4,5-Dichloro-2,3-dimethoxypyridine (CAS 1881291-78-6)
- 4-Chloro-5-fluoroindolin-2-one (CAS 103585-71-3)
- 1-Iodo-3-(prop-2-yn-1-yloxy)benzene (CAS 1250524-15-2)
- 4-Cyclopropoxy-2-fluoronicotinamide (CAS 1243452-13-2)
- 4,7-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-[1,2,5]thiadiazolo[3,4-c]pyridine (CAS 1883586-01-3)
- KHS101 (CAS 1262770-73-9)
- n-Allyl-n-((benzyloxy)carbonyl)glycine (CAS 71931-22-1)
- Prolactin-Releasing Peptide (1-31) (rat) (CAS 215510-06-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com