4-fluoro-2-(trifluoromethyl)-1H-1,3-benzodiazole CAS 18645-92-6
| CAS No. | 18645-92-6 |
| Molecular Formula | C8H4F4N2 |
| Molecular Weight | 204.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 4-fluoro-2-(trifluoromethyl)-1H-1,3-benzodiazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
4-fluoro-2-(trifluoromethyl)-1H-1,3-benzodiazole (CAS 18645-92-6) is a high-purity analytical reference standard with the molecular formula C8H4F4N2 and a molecular weight of 204.12 g/mol.
The molecular framework of 4-fluoro-2-(trifluoromethyl)-1H-1,3-benzodiazole (C8H4F4N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H4F4N2 |
| Molecular Weight | 204.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related fluoro Standards
- 2-Fluoro-4-(trifluoromethyl)pyridine-3-acetonitrile (CAS 1227511-79-6)
- 2-Fluoro-5-(trifluoromethyl)pyridine-4-acetonitrile (CAS 1227512-10-8)
- 2-Fluoro-3-(trifluoromethyl)pyridine-4-acetonitrile (CAS 1227513-68-9)
- 6-Fluoro-2-(trifluoromethyl)pyridine-3-acetonitrile (CAS 1227514-04-6)
- 3-Fluoro-2-(trifluoromethyl)pyridine-4-acetonitrile (CAS 1227514-88-6)
- 2-Fluoro-6-(trifluoromethyl)pyridine-3-acetonitrile (CAS 1227580-08-6)
- 3-Fluoro-5-(trifluoromethyl)pyridine-2-acetonitrile (CAS 1227592-18-8)
- 2-Fluoro-5-(trifluoromethyl)pyridine-3-acetonitrile (CAS 1227600-17-0)
Recommended Standards
- 2-Amino-6-fluoro-4-(trifluoromethyl)benzonitrile (CAS 1807176-08-4)
- 2-Amino-3-fluoro-6-(trifluoromethyl)benzonitrile (CAS 186517-08-8)
- 2-(2-(Difluoromethyl)-4,6-difluoropyridin-3-yl)acetonitrile (CAS 1806821-20-4)
- Sodium 5-amino-2-nitrobenzoate (CAS 1951444-76-0)
- 3-(Trifluoromethyl)-2-(3,3,3-trifluoropropoxy)pyridine 1774897-87-8 (CAS 1774897-87-8)
- 1-Benzyl 5-methyl (2R)-2-{[(benzyloxy)carbonyl]amino}pentanedioate (CAS 1820570-17-9)
- 5-Chloro-3-methyl-1H-pyrazole (CAS 15953-45-4)
- (S)-1-(3-(tert-butyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-4-yl)-2,5-diphenyl-1H-pyrrole (CAS 1683581-58-9)
- 6,7-Dihydro-5H-cyclopenta[b]pyridine-6-carboxylic acid (CAS 591768-76-2)
- Methyl 2-(((3-ethylisoxazol-5-yl)methyl)thio)acetate (CAS 1160246-41-2)
- Benzo[lmn][3,8]phenanthroline (CAS 194-00-3)
- 1-(4-Butoxy-3-chlorophenyl)ethanone (CAS 15560-50-6)
- Ethyl 6-chloro-4-(methylamino)pyridine-3-carboxylate (CAS 449811-28-3)
- Semaglutide impurity 59 (CAS CATO-C4X-222659)
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