3-[(tert-Butyldimethylsilyl)oxy]-2-fluorophenol CAS 186584-62-3
| CAS No. | 186584-62-3 |
| Molecular Formula | C12H19FO2Si |
| Molecular Weight | 242.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies 3-[(tert-Butyldimethylsilyl)oxy]-2-fluorophenol (CAS 186584-62-3), a certified reference material (molecular formula C12H19FO2Si, MW 242.36 g/mol) for analytical method development and quality control.
The molecular framework of 3-[(tert-Butyldimethylsilyl)oxy]-2-fluorophenol (C12H19FO2Si) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H19FO2Si |
| Molecular Weight | 242.36 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | F-containing |
Related tert Standards
- 5-[(tert-Butyldimethylsilyl)oxy]-2-fluorophenol (CAS 113984-74-0)
- 2-[(tert-Butyldimethylsilyl)oxy]-6-fluorophenol (CAS 172832-49-4)
- 3-[(tert-Butyldimethylsilyl)oxy]-4-fluorophenol (CAS 1881329-11-8)
- 2-(1-(((tert-Butyldimethylsilyl)oxy)methyl)cyclobutyl)acetaldehyde (CAS 1219088-70-6)
- 3-(2-((tert-Butyldimethylsilyl)oxy)ethyl)cyclopentanone (CAS 93131-85-2)
- 3-[tert-Butyldimethylsilyl]oxy-1-propyn-1-yl]trimethyl-silane (CAS 83578-59-0)
- 3-((tert-Butyldimethylsilyl)oxy)-1-hydroxy-3-methylcyclobutane-1-carbonitrile (CAS 2765503-76-0)
- 3-(2-((tert-Butyldimethylsilyl)oxy)ethyl)oxetane-3-carbonitrile (CAS 2283378-70-9)
Recommended Standards
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