2-Methyl-3-nitropyridine-4-carboxylic acid CAS 18699-86-0
| CAS No. | 18699-86-0 |
| Molecular Formula | C7H6N2O4 |
| Molecular Weight | 182.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Methyl-3-nitropyridine-4-carboxylic acid (CAS 18699-86-0), molecular formula C7H6N2O4 and molecular weight 182.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Methyl-3-nitropyridine-4-carboxylic acid (C7H6N2O4) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6N2O4 |
| Molecular Weight | 182.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Nitrogen Atoms | 2 |
Related Methyl Standards
- Methyl 3-Nitropyridine-2-carboxylate (CAS 103698-08-4)
- 4-Methyl-5-nitropyridine-2-carboxylic acid (CAS 5832-43-9)
- 4-Methyl-6-nitropyridine-3-carboxylic acid (CAS 60780-86-1)
- 6-Methyl-3-nitropyridine-2-carboxylic acid (CAS 21203-64-5)
- 6-Methyl-4-nitropyridine-2-carboxylic acid (CAS 30235-16-6)
- 6-Methyl-5-nitropyridine-2-carboxylic acid (CAS 24194-98-7)
- Methyl 6-nitropyridine-2-carboxylate (CAS 26218-74-6)
- 5-Nitropyridine-2-carbonyl chloride (CAS 59290-88-9)
Recommended Standards
- Ethyl isoxazolo[5,4-c]isoxazole-3-carboxylate (CAS 183666-51-5)
- (2e)-3-(2,4-Dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)prop-2-enoic acid (CAS 57412-59-6)
- 3-Hydroxy-4-nitrobenzamide (CAS 182932-64-5)
- 1-Methylfuro[3,4-d]pyrimidine-2,4,7(1H,3H,5H)-trione (CAS 88999-95-5)
- Ceftobiprole medocaril (CAS 376653-43-9)
- 2-(4-(4-Methoxyphenyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetonitrile (CAS 861206-05-5)
- Benzyl (4-(methylamino)cyclohexyl)carbamate (CAS 1353971-24-0)
- (E)-4-(6-Bromo-1H-indol-3-yl)but-3-en-2-one (CAS 654649-67-9)
- 1-(4-Methylphenyl)-1H-1,2,3,4-tetrazole-5-thiol (CAS 13980-77-3)
- tert-Butyl 4-(6-aminopyridin-2-yl)piperidine-1-carboxylate (CAS 478366-40-4)
- Enterolactone (CAS 78473-71-9)
- 1-Amino-3-phenylpentan-3-ol (CAS 91339-23-0)
- 4-(((1H-Benzo[d][1,2,3]triazol-1-yl)methyl)amino)benzoic acid (CAS 62001-43-8)
- D-Asp15-Tirzepatide (CAS CATO-CPTD788919)
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