(S)-2-(2-amino-3-phenylpropyl)isoindoline-1,3-dione (Hydrochloride) CAS 187526-95-0
| CAS No. | 187526-95-0 |
| Molecular Formula | C17H16N2O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(S)-2-(2-amino-3-phenylpropyl)isoindoline-1,3-dione (Hydrochloride) (CAS 187526-95-0), molecular formula C17H16N2O2HCl and molecular weight 316.78 g/mol, is a CATO reference standard with documented purity and traceability.
(S)-2-(2-amino-3-phenylpropyl)isoindoline-1,3-dione (Hydrochloride) (C17H16N2O2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H16N2O2 HCl |
| Molecular Weight | 316.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 2-(3-Chloro-4-nitrophenyl)-4-phenylcyclohexan-1-one (CAS 1980086-54-1)
- 3-(2-Aminoethyl)-1h-indole-5-carboxylic acid (CAS 74884-75-6)
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- 2,2,2-Trifluoroethyl n-(2-methoxy-5-methylphenyl)carbamate (CAS 1087788-53-1)
- 2-Ethyl-2H-benzo[e][1,2]oxazine-6-carboxylic acid (CAS 1186388-92-0)
- N-(4-bromo-3-methylphenyl)-2-(4-phenylpiperazin-1-yl)acetamide (CAS 882080-82-2)
- 5-Bromo-1-fluoro-2-iodo-3-methylbenzene (CAS 1805553-01-8)
- Erlotinib Impurity 180 (CAS 127791-53-1)
- 3'-Chloro-[1,1'-biphenyl]-3-carboxylicacid (CAS 168619-06-5)
- Semaglutide impurity 227 (CAS CATO-C4X-2226227)
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