Bis(chloromethyl)(phenyl)phosphine oxide CAS 18788-46-0
| CAS No. | 18788-46-0 |
| Molecular Formula | C8H9Cl2OP |
| Molecular Weight | 223.04 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Bis(chloromethyl)(phenyl)phosphine oxide (C8H9Cl2OP) contains organophosphorus functionality, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Bis(chloromethyl)(phenyl)phosphine oxide (CAS 18788-46-0) is a high-purity analytical reference standard with the molecular formula C8H9Cl2OP and a molecular weight of 223.04 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9Cl2OP |
| Molecular Weight | 223.04 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
Related Bis Standards
- 1-(4,5-Bis(chloromethyl)thiophen-2-yl)ethan-1-one (CAS 7345-75-7)
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- 5-(Chloromethyl)-1-ethyl-2-methanesulfonyl-1h-imidazole (CAS 1221341-11-2)
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Recommended Standards
- (3'-Cyano-[1,1'-biphenyl]-4-yl)boronic acid (CAS 1352715-67-3)
- (2-(3-Hydroxypyrrolidin-1-yl)-4-methylpyrimidin-5-yl)boronic acid (CAS 2225152-74-7)
- (4'-Cyano-[1,1'-biphenyl]-2-yl)boronic acid (CAS 1265312-65-9)
- (4-Methyl-2-morpholinopyrimidin-5-yl)boronic acid (CAS 2077990-06-6)
- 7-Methyl-4-(trifluoromethyl)bicyclo[4.2.0]Octa-1,3,5-trien-7-amine (CAS 1128112-22-0)
- (S)-cyclopropyl(3-fluoro-5-(trifluoromethyl)phenyl)methanamine (CAS 1213097-40-5)
- 1-Fluoro-4-(((trifluoromethyl)sulfonyl)methyl)benzene (CAS 2408-04-0)
- Thevetin A DISCONTINUED (CAS 37933-66-7)
- 1-(Piperidin-4-yl)azepane dihydrochloride (CAS 871112-73-1)
- 1-Fluoro-4-(trichloromethoxy)benzene (CAS 407-13-6)
- 3',4,5'-Trifluoro-[1,1'-biphenyl]-3-amine (CAS 1226211-84-2)
- 6-Fluoroisoindolin-5-ol hydrobromide (CAS 1447607-11-5)
- 4-(4-Chlorophenyl)morpholine (CAS 70291-67-7)
- D-Phe6-Tirzepatide (CAS CATO-CPTD788925)
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