3-Chloro-4-fluoro-5-methylaniline CAS 187929-77-7
| CAS No. | 187929-77-7 |
| Molecular Formula | C7H7ClFN |
| Molecular Weight | 159.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-Chloro-4-fluoro-5-methylaniline is closely related to a nitrile group, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-Chloro-4-fluoro-5-methylaniline (CAS 187929-77-7) is a high-purity analytical reference standard with the molecular formula C7H7ClFN and a molecular weight of 159.59 g/mol.
Owing to a nitrile group, fluorine/chlorine substitution, an aromatic ring system, 3-Chloro-4-fluoro-5-methylaniline is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 159.59 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Chloro-4-fluoro-5-methylaniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H7ClFN |
| Molecular Weight | 159.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 4-Chloro-2-fluoro-3-methylaniline (CAS 1000590-85-1)
- 3-Chloro-2-fluoro-N-methylaniline (CAS 1040041-75-5)
- 2-chloro-3-fluoro-N-methylaniline (CAS 1070892-67-9)
- (3-Chloro-5-fluorophenyl)methanamine (CAS 1070892-68-0)
- 2-Chloro-5-fluoro-n-methylaniline (CAS 1070892-72-6)
- 4-Chloro-3-fluoro-2-methylaniline (CAS 1096113-25-5)
- 5-Chloro-2-fluoro-N-methylaniline (CAS 1156149-56-2)
- 2-Chloro-4-fluoro-5-methylaniline (CAS 124185-35-9)
Recommended Standards
- 2-(1-Chloroethyl)-3-fluoropyridine (CAS 1824538-00-2)
- (2-Chloro-3-fluorophenyl)methanamine (CAS 72235-54-2)
- 5-Chloro-3-fluoro-2-methylaniline (CAS 1807166-90-0)
- (3-Chloro-2-fluorophenyl)methanamine (CAS 72235-55-3)
- 5-(Piperidin-4-yloxy)pyrimidine (CAS 1211529-16-6)
- (1S,2S)-1,2-bis(3,5-dimethylphenyl)ethane-1,2-diamine (CAS 158391-59-4)
- 3-Phenylthiazolo[5,4-d]isoxazol-5-amine (CAS 193345-25-4)
- Methyl 2-(4-fluoro-2-methylphenyl)-2-oxoacetate (CAS 334477-07-5)
- 3-(Pyridin-4-yl)-4,5,6,7-tetrahydro-1H-indazol-4-amine (CAS 1710202-60-0)
- 5,11-Bis(phenylsulfonyl)dibenzo[a,e]cyclooctene (CAS 468751-39-5)
- Butyl ethenyl(methyl)phosphinate (CAS 5238-94-8)
- 2-(2-Aminoethyl)-1,2-dihydrophthalazin-1-one (CAS 215524-15-5)
- 4'-Chloro-3-fluoro-[1,1'-biphenyl]-2-carboxylic acid (CAS 1261921-07-6)
- Fas C- Terminal Tripeptide (CAS 189109-90-8)
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