4-[(tert-butyldimethylsilyl)oxy]-2,6-difluorophenol CAS 1881327-86-1
| CAS No. | 1881327-86-1 |
| Molecular Formula | C12H18F2O2Si |
| Molecular Weight | 260.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-[(tert-butyldimethylsilyl)oxy]-2,6-difluorophenol.
4-[(tert-butyldimethylsilyl)oxy]-2,6-difluorophenol (CAS 1881327-86-1), molecular formula C12H18F2O2Si and molecular weight 260.35 g/mol, is a CATO reference standard with documented purity and traceability.
4-[(tert-butyldimethylsilyl)oxy]-2,6-difluorophenol (C12H18F2O2Si) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H18F2O2Si |
| Molecular Weight | 260.35 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
Related tert Standards
- 4-[(tert-Butyldimethylsilyl)oxy]-2,3-difluorophenol (CAS 1881289-55-9)
- 7-((tert-Butyldimethylsilyl)oxy)heptanoic acid (CAS 77744-45-7)
- (5-(((tert-Butyldimethylsilyl)oxy)-methyl)thiazol-2-yl)methanol (CAS 1381778-87-5)
- 1-(tert-Butyldimethylsilyl)indole-5-carbaldehyde (CAS 946077-36-7)
- 2-(Tert-butyldimethylsilyl)isoindoline-1,3-dione (CAS 79293-84-8)
- 2-((tert-Butyldimethylsilyl)oxy)-N-methoxy-N,2-dimethylpropanamide (CAS 1219970-52-1)
- 3-[(tert-Butyldimethylsilyl)oxy]-4-chlorophenol (CAS 1197814-23-5)
- 4-[(tert-Butyldimethylsilyl)oxy]-2-chlorophenol (CAS 1600530-39-9)
Recommended Standards
- 1-(4-Methyl-2-(phenethylamino)thiazol-5-yl)ethan-1-one (CAS 196797-05-4)
- 2-(Naphthalen-2-yl)benzo[b]thiophene (CAS 17164-77-1)
- (2S)-2-amino-3-phenyl-N-(thiophen-2-ylmethyl)propanamide (CAS 762215-56-5)
- 2-((2-Cyclobutylthiazol-4-yl)methoxy)aniline (CAS 1707734-82-4)
- 7-Formyl-1-benzofuran-2-carboxylic acid (CAS 1782910-29-5)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidine-4,6(5H)-dione (CAS 339018-06-3)
- Benzyl 5-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylate (CAS 1643573-74-3)
- 3-Amino-2-fluoro-N-methylbenzamide (CAS 1332300-71-6)
- 4-(2-Phenylpropan-2-yl)aniline hydrochloride (CAS 1416354-38-5)
- Donepezil EP impurity F (CAS 145546-80-1)
- 714291-12-0 7-Chloro-N-isopropyl-4-nitro-2,1,3-benzoxadiazol-5-amine MFCD05684374 (CAS 714291-12-0)
- N1-(Pyridin-4-yl)benzene-1,4-diamine dihydrochloride (CAS 1909337-69-4)
- 2-Bromo-4-(2-methoxy-ethoxy)-phenol (CAS 52076-14-9)
- Semaglutide Impurity 151 xTFA (CAS CATO-C4X-2226151)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com