2-Fluoro-3-nitropyridine hydrate CAS 1881328-77-3
| CAS No. | 1881328-77-3 |
| Molecular Formula | C5H3FN2O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Fluoro-3-nitropyridine hydrate (CAS 1881328-77-3) is a high-purity analytical reference standard with the molecular formula C5H3FN2O2H2O and a molecular weight of 160.10 g/mol.
The molecular framework of 2-Fluoro-3-nitropyridine hydrate (C5H3FN2O2H2O) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H3FN2O2 H2O |
| Molecular Weight | 160.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluoro Standards
- 4-[(2-Fluoro-4-nitrophenoxy)methyl]-1-methylpiperidine (CAS 1000052-54-9)
- 3-Fluoro-4-((1-methylpiperidin-4-yl)methoxy)aniline (CAS 1000053-56-4)
- 2-Fluoro-5-iodo-4-methoxybenzoic acid (CAS 1000162-78-6)
- Ethyl 4-fluoro-3-ethoxybenzoate (CAS 1000207-63-5)
- 6-fluoro-4-iodo-1H-benzo[d]imidazole (CAS 1000308-33-7)
- 2-Fluoro-3-hydroxybenzonitrile (CAS 1000339-24-1)
- 1-(5-Fluoro-2-methylphenyl)pyrrolidine (CAS 1000339-32-1)
- 3-Fluoro-2-nitrobenzoic Acid (CAS 1000339-51-4)
Recommended Standards
- tert-Butyl 3-((4-chloro-6-methylpyrimidin-2-yl)amino)pyrrolidine-1-carboxylate (CAS 1261231-42-8)
- 2-(Naphthalen-2-yl)nicotinic acid (CAS 1262000-45-2)
- (2S)-2-(Dimethylamino)propane-1-thiol (CAS 1807890-91-0)
- 2-((4-Carbamoylphenyl)carbamoyl)cyclopropane-1-carboxylic acid (CAS 866151-34-0)
- 2,3-Difluoro-5-sulfamoylbenzoic acid (CAS 716361-75-0)
- 2,5-dichloro-4'-piperidinomethyl benzophenone (CAS 898775-67-2)
- 3-((4-Ethylcyclohexyl)amino)propan-1-ol (CAS 1042551-60-9)
- 4-Bromo-5-methyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole (CAS 2158298-26-9)
- N-[2-(Dimethylamino)ethyl]-2-(methylamino)-acetamide dihydrochloride (CAS 1220037-40-0)
- Neuropeptide AF (human) (CAS 192387-38-5)
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