(E)-2-Iodo-3-phenylacrylic acid CAS 18819-62-0
| CAS No. | 18819-62-0 |
| Molecular Formula | C9H7IO2 |
| Molecular Weight | 274.06 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 274.06 g/mol gives (E)-2-Iodo-3-phenylacrylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
(E)-2-Iodo-3-phenylacrylic acid (CAS 18819-62-0), molecular formula C9H7IO2 and molecular weight 274.06 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system, (E)-2-Iodo-3-phenylacrylic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 274.06 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H7IO2 |
| Molecular Weight | 274.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | I-containing |
Related E Standards
- 3-Iodo-4-methoxy-1H-pyrrolo[3,2-c]pyridine (CAS 1000341-25-2)
- 3-Iodo-7-methoxyimidazo[1,2-a]pyridine (CAS 1036990-97-2)
- 3-Iodo-6-methoxyimidazo[1,2-a]pyridine (CAS 1044733-64-3)
- 5-iodo-6-methoxy-1H-indazole (CAS 1082041-59-5)
- 3-Iodo-1-methyl-1H-pyrazolo[3,4-b]pyridin-5-amine (CAS 1093871-50-1)
- 3-Iodo-6-methoxy-2H-indazole (CAS 1150618-46-4)
- 4-Iodo-6-methoxy-1H-pyrrolo[2,3-b]pyridine (CAS 1190310-42-9)
- 3-Iodo-7-methyl-1H-indazol-6-ol (CAS 1190312-94-7)
Recommended Standards
- 5-CHLOROMETHYL-3-(4-CHLORO-3-NITRO-PHENYL)-[1,2,4]OXADIAZOLE (CAS 187399-90-2)
- 1-(2-Bromo-5-(trifluoromethyl)thiazol-4-yl)ethan-1-one (CAS 1935614-24-6)
- 3-Iodo-1-methyl-1H-indazol-7-ol (CAS 1823954-66-0)
- 2-(Hydroxymethyl)-5-iodobenzimidazole (CAS 1935632-45-3)
- tert-butyl 4-oxo-3-(oxolan-3-yl)piperidine-1-carboxylate (CAS 1694531-32-2)
- 3-(5-methyl-1,2,4-oxadiazol-3-yl)aniline (CAS 10185-69-0)
- 4-((4-Ethoxyphenyl)amino)-2-(4-methylpiperazin-1-yl)-4-oxobutanoic acid (CAS 899745-13-2)
- Paclitaxel EP Impurity F (CAS 153083-53-5)
- 2-((((Benzyloxy)carbonyl)amino)methyl)cyclohexane-1-carboxylic acid (CAS 1497245-23-4)
- Dabrafenib Impurity 6 (CAS CATO-C4X-30336)
- 2-(Difluoromethyl)-3-hydroxy-4-iodo-6-(trifluoromethoxy)pyridine (CAS 1803941-55-0)
- 6-Chloro-2,3,4-trimethylpyridine (CAS 408314-12-5)
- 3-methylpyrazole (CAS 1453-58-3)
- Semaglutide Impurity 155 (x TFA Salt) (CAS CATO-C4X-2226155)
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