Ketoprofen EP Impurity E CAS 188252-75-7
| CAS No. | 188252-75-7 |
| Molecular Formula | C16H15NO2 |
| Molecular Weight | 253.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ketoprofen EP Impurity E (CAS 188252-75-7, C16H15NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ketoprofen EP Impurity E (C16H15NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ketoprofen EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H15NO2 |
| Molecular Weight | 253.30 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Nitrogen Atoms | 1 |
Related Ketoprofen Standards
- Ketoprofen EP Impurity E (CAS 59512-16-2)
- R-Ketoprofen Tromethamine Salt (CAS 167300-68-7)
- Ketoprofen Impurity 110 (CAS 73721-00-3)
- Ketoprofen Impurity 13 (CAS 56105-81-8)
- Ketoprofen (CAS 22071-15-4)
- Ketoprofen Impurity 111 (CAS CATO-C4X-1471111)
- Ketoprofen Impurity 14 (CAS 59960-32-6)
- Ketoprofen Impurity 23 (CAS CATO-C4X-147123)
Recommended Standards
- Parecoxib sodium Impurity 18 (CAS 181696-73-1)
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- Perindopril Impurity 96 (CAS CATO-C4X-125296)
- Ozanimod Impurity 14 (CAS CATO-C4X-290214)
- Melphalan Impurity 35 (CAS CATO-C4X-198835)
- Baclofen impurity 15 (CAS CATO-C4X-101215)
- (E)-2-(((2-fluoro-5-methylphenyl)imino)methyl)phenol (CAS 460315-17-7)
- (S)-1-(Pyridin-2-yl)propan-1-amine hydrochloride (CAS 339312-61-7)
- Benzyl (3-fluoro-4-(3-oxopyrrolidin-1-yl)phenyl)carbamate (CAS 1021088-77-6)
- N-[4-(4-Chloro-3-methylphenyl)-1,3-thiazol-2-yl]pyridin-3-amine (CAS 1023483-44-4)
- 2-bromo-1-methyl-benzimidazole (CAS 49572-60-3)
- 1-(Bicyclo[2.2.1]Heptan-2-yl)-N-methylmethanamine (CAS 15907-66-1)
- Semaglutide Impurity 16 (CAS CATO-C4X-222616)
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