1R 3S 4R-Ent-Entecavir CAS 188399-46-4
| CAS No. | 188399-46-4 |
| Molecular Formula | C12H15N5O3 |
| Molecular Weight | 277.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1R 3S 4R-Ent-Entecavir is closely related to an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1R 3S 4R-Ent-Entecavir (CAS 188399-46-4), molecular formula C12H15N5O3 and molecular weight 277.28 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1R 3S 4R-Ent-Entecavir (C12H15N5O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1R 3S 4R-Ent-Entecavir under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H15N5O3 |
| Molecular Weight | 277.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Nitrogen Atoms | 5 |
Recommended Standards
- Entecavir (CAS 142217-69-4)
- Entecavir EP Impurity D (CAS 1367369-80-9)
- Erlotinib Impurity 20 (CAS 938185-06-9)
- Entecavir Impurity 17 (CAS CATO-C4X-107717)
- 2-Phenyltetrahydro-2H-pyran-4-amine hydrochloride (CAS 1803582-99-1)
- Citreorosein (CAS 481-73-2)
- 5-(Trifluoromethyl)nicotinaldehyde (CAS 131747-67-6)
- Parecoxib sodium Impurity 20 (CAS 952-06-7)
- 6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazin-6-amine hydrochloride (CAS 2705222-77-9)
- 5-Amino-2-chlorobenzoic acid compound with sulfuric acid (1:1) (CAS 37984-73-9)
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- 2-Propenoic acid, octyl ester, homopolymer (CAS 25266-13-1)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com