Nizatidine EP Impurity E CAS 188666-11-7
| CAS No. | 188666-11-7 |
| Molecular Formula | C11H18N4O3S2 |
| Molecular Weight | 318.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Nizatidine EP Impurity E (C11H18N4O3S2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Nizatidine EP Impurity E (CAS 188666-11-7, C11H18N4O3S2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H18N4O3S2 |
| Molecular Weight | 318.42 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2010 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 2 |
Related Nizatidine Standards
- Nizatidine N-Desmethyl Metabolite (CAS 82586-78-5)
- Nizatidine (CAS 76963-41-2)
- Nizatidine-d3 (CAS 1246833-99-7)
- Nizatidine N-Oxide (CAS 102273-12-1)
- Nizatidine EP Impurity C (CAS 102273-13-2)
- Nizatidine EP Impurity I (CAS 82586-81-0)
- Nizatidine impurity 17 (CAS CATO-C4X-138017)
- Nizatidine impurity 16 (CAS CATO-C4X-138016)
Recommended Standards
- N-(1-(4-Aminobenzyl)pyrrolidin-3-yl)isoquinolin-5-amine (CAS 675133-16-1)
- Fluticasone Impurity N9 (CAS 3863-16-9)
- N-(1-(3-Aminobenzyl)pyrrolidin-3-yl)isoquinolin-5-amine (CAS 675133-14-9)
- Butyl 4-(2-mercapto-4,4-dimethylpyrimidin-1(4H)-yl)benzoate (CAS 1142213-28-2)
- Letermovir Impurity 13 (CAS CATO-C4X-291513)
- Avacopan Impurity 1 (CAS CATO-C4X-29451)
- Ixabepilone Impurity 3 (CAS 219989-85-2)
- (2-Fluorophenyl)(1-methyl-1h-imidazol-2-yl)methanamine (CAS 874623-45-7)
- 4-bromo-6-fluoro-3H-1,3-benzoxazol-2-one (CAS 2387595-42-6)
- Methyl 3-bromo-4-(hydroxymethyl)benzoate (CAS 90326-62-8)
- Bortezomib Impurity 26 (CAS CATO-C4X-107226)
- Venlafaxine Impurity 33 (CAS 1062607-49-1)
- 2-(2-Fluoro-5-methylphenyl)-4,5-dihydro-1H-imidazole (CAS 208718-14-3)
- Peptide-GMF (CAS CATO-CPTD788469)
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