3-(3,3-Difluorocyclobutyl)aniline CAS 1889232-33-0
| CAS No. | 1889232-33-0 |
| Molecular Formula | C10H11F2N |
| Molecular Weight | 183.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(3,3-Difluorocyclobutyl)aniline.
CATO supplies 3-(3,3-Difluorocyclobutyl)aniline (CAS 1889232-33-0), a certified reference material (molecular formula C10H11F2N, MW 183.20 g/mol) for analytical method development and quality control.
Structurally, 3-(3,3-Difluorocyclobutyl)aniline (C10H11F2N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 183.20 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11F2N |
| Molecular Weight | 183.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluorocyclobutyl Standards
- 4-(3,3-Difluorocyclobutyl)aniline (CAS 1547145-65-2)
- (3,3-Difluorocyclobutyl)methanesulfonamide (CAS 1850911-31-7)
- N-(3,3-Difluorocyclobutyl)sulfamide (CAS 1866130-01-9)
- N-(3,3-difluorocyclobutyl)thietan-3-amine (CAS 1855843-20-7)
- 1-((3,3-Difluorocyclobutyl)methyl)-1H-pyrazol-4-amine (CAS 1851327-57-5)
- (1-(3,3-Difluorocyclobutyl)-1H-pyrazol-4-yl)methanamine (CAS 2379590-15-3)
- 5-(3,3-difluorocyclobutyl)-1H-pyrazol-3-amine (CAS 1425931-95-8)
- 1-(3,3-Difluorocyclobutyl)piperidin-4-one (CAS 2016211-15-5)
Recommended Standards
- 2-Amino-4,5-dimethoxybenzyl Alcohol (CAS 188174-23-4)
- 3-Oxooctahydroindolizine-6-carboxylic acid (CAS 1934599-03-7)
- 2,6-Dimethoxy-5-methylpyridine-3-methanol (CAS 1879026-22-8)
- 5-Fluoro-2-methoxybenzo[d]thiazole (CAS 1935219-93-4)
- 2-Methoxyethyl 1-(4-amino-1,2,5-oxadiazol-3-yl)-5-methyl-1H-1,2,3-triazole-4-carboxylate (CAS 312508-59-1)
- (5-Methyl-2-propoxyphenyl)boronic acid (CAS 480438-70-8)
- 4-(Piperidin-4-yl)pyrrolidin-2-one (CAS 1565677-59-9)
- 5-Bromo-2-(2-(dimethylamino)ethoxy)aniline (CAS 946743-19-7)
- 2-(4-Chloro-6-methylpyrimidin-2-yl)ethanamine (CAS 933683-21-7)
- 2,5-Dimethoxyphenyl acetate (CAS 27257-06-3)
- 2-(3-Chlorophenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carboxylic acid (CAS 68321-63-1)
- (2-Chloro-5-cyclopropyl-4-methoxyphenyl)boronic acid (CAS 2225178-55-0)
- n-Methyl-1-(2-(trifluoromethyl)phenyl)methanamine (CAS 296276-41-0)
- A-18-F-NH2; Morphine Modulating Neuropeptide (CAS 99588-52-0)
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