4,5-Difluorophthalic Anhydride CAS 18959-30-3
| CAS No. | 18959-30-3 |
| Molecular Formula | C8H2F2O3 |
| Molecular Weight | 184.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4,5-Difluorophthalic Anhydride (C8H2F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4,5-Difluorophthalic Anhydride (CAS 18959-30-3), molecular formula C8H2F2O3 and molecular weight 184.10 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4,5-Difluorophthalic Anhydride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H2F2O3 |
| Molecular Weight | 184.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | F-containing |
Related Difluorophthalic Standards
Recommended Standards
- 2,5-Difluoro-4-nitrobenzonitrile (CAS 172921-32-3)
- 2,4-Difluoro-5-nitrobenzonitrile (CAS 67152-20-9)
- 2,5-Difluoro-3-nitrobenzonitrile (CAS 1690818-46-2)
- 2-Oxo-2H-pyran-4,6-dicarboxylic acid (CAS 72698-24-9)
- 5-(O-tolyl)-1,3,4-oxadiazol-2-amine (CAS 1750-78-3)
- 3-Hydrazinyl-4,5-diphenyl-4h-1,2,4-triazole (CAS 374088-47-8)
- (2-(6-Amino-2-methylpyridin-3-yl)pyrrolidin-1-yl)(phenyl)methanone (CAS 1352522-09-8)
- 5,7-Difluoro-3-methyl-1H-indole-2-carboxylic acid (CAS 1785399-14-5)
- Ethyl ((benzyloxy)carbonyl)cysteinate (CAS 1396979-03-5)
- 2-(Bromomethyl)-5-(difluoromethyl)-3-hydroxypyridine-6-carboxylic acid (CAS 1805534-91-1)
- (R)-4-((5-(Diethylamino)pentan-2-yl)amino)quinolin-7-ol (CAS 645406-57-1)
- 3-Methylbutyl 2-Methylbutanoate (CAS 27625-35-0)
- Methyl 6-amino-4-chloropicolinate (CAS 179555-07-8)
- Atrial Natriuretic Polypeptide (4-28), human (CAS 95896-08-5)
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