3-(2,2-Difluorocyclopropyl)benzoic acid CAS 1896596-74-9
| CAS No. | 1896596-74-9 |
| Molecular Formula | C10H8F2O2 |
| Molecular Weight | 198.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(2,2-Difluorocyclopropyl)benzoic acid.
3-(2,2-Difluorocyclopropyl)benzoic acid (CAS 1896596-74-9) is a high-purity analytical reference standard with the molecular formula C10H8F2O2 and a molecular weight of 198.17 g/mol.
The molecular framework of 3-(2,2-Difluorocyclopropyl)benzoic acid (C10H8F2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-(2,2-Difluorocyclopropyl)benzoic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H8F2O2 |
| Molecular Weight | 198.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
Related Difluorocyclopropyl Standards
- 4-(2,2-Difluorocyclopropyl)benzoic Acid (CAS 1889432-53-4)
- 2-(2,2-Difluorocyclopropyl)benzoic acid (CAS 1897870-50-6)
- (4-(2,2-Difluorocyclopropyl)phenyl)boronic acid (CAS 1464140-20-2)
- 1-(2,2-Difluorocyclopropyl)-3-nitrobenzene (CAS 54672-46-7)
- 2-(2,2-Difluorocyclopropyl)-3-fluorobenzaldehyde (CAS 2755372-45-1)
- 2-(2,2-difluorocyclopropyl)ethanesulfonyl chloride (CAS 1989672-13-0)
- (2,2-Difluorocyclopropyl)methanesulfonyl chloride (CAS 1260671-57-5)
- 4-((2,2-Difluorocyclopropyl)methyl)piperazin-2-one (CAS 1393541-17-7)
Recommended Standards
- (E)-Methyl 3-(2,4-difluorophenyl)acrylate (CAS 186758-21-4)
- (1R,2R)-2-(2,3-difluorophenyl)cyclopropane-1-carboxylic acid (CAS 1955548-02-3)
- 1-(3,4-Difluorophenyl)cyclopropanecarboxylic Acid (CAS 186347-67-1)
- Methyl 2,6-Dihydroxy-4-Methoxybenzoate (CAS 19722-76-0)
- N6,N6-Dimethyl-N2-[(benzyloxy)carbonyl]-L-lysine tert-Butyl Ester (CAS 204074-50-0)
- 3-(Dimethylamino)-N-(2-morpholino-5-(trifluoromethyl)phenyl)benzamide (CAS 327975-89-3)
- diethyl(2-phenoxyethyl)amine hydrochloride (CAS 21663-15-0)
- 1-((2-Fluorophenoxy)methyl)cyclopentan-1-ol (CAS 1465500-09-7)
- 3-((3-Bromobenzyl)oxy)azetidine (CAS 1121634-25-0)
- 2-Bromo-3-(2,4-difluorophenyl)-1-propene (CAS 951893-44-0)
- N-Cyclopropyl-N-[1-(2-hydroxy-ethyl)-piperidin-4-ylmethyl]-acetamide (CAS 1353975-46-8)
- 1-[(2,6-dichlorophenyl)methyl]-5-methyl-1h-pyrazol-3-amine (CAS 956440-98-5)
- Pilocarpine (CAS 92-13-7)
- Semaglutide Impurity 128 (CAS 2490269-78-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com