1-{8-chloro-4,10-dioxatricyclo[7.3.0.0³,⁷]dodeca-1,3(7),5,8,11-pentaen-2-yl}ethan-1-one CAS 1897757-36-6
| CAS No. | 1897757-36-6 |
| Molecular Formula | C12H7ClO3 |
| Molecular Weight | 234.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-{8-chloro-4,10-dioxatricyclo[7.3.0.0³,⁷]dodeca-1,3(7),5,8,11-pentaen-2-yl}ethan-1-one.
1-{8-chloro-4,10-dioxatricyclo[7.3.0.0³,⁷]dodeca-1,3(7),5,8,11-pentaen-2-yl}ethan-1-one (CAS 1897757-36-6), molecular formula C12H7ClO3 and molecular weight 234.64 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-{8-chloro-4,10-dioxatricyclo[7.3.0.0³,⁷]dodeca-1,3(7),5,8,11-pentaen-2-yl}ethan-1-one (C12H7ClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1-{8-chloro-4,10-dioxatricyclo[7.3.0.0³,⁷]dodeca-1,3(7),5,8,11-pentaen-2-yl}ethan-1-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H7ClO3 |
| Molecular Weight | 234.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
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Recommended Standards
- 2-Chloro-3-nitro-6-phenylpyridine (CAS 187242-88-2)
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- 2-(2-Chlorophenyl)pyrimidine-5-carboxylic acid (CAS 928712-83-8)
- 2-[4-(Boc-amino)-1-piperidinyl]pyridine-5-boronic acid pinacol ester, 96% (CAS 1042917-44-1)
- 2-[2-(4-Chlorophenyl)adamantan-2-yl]-1-(pyrrolidin-1-yl)ethan-1-one (CAS 400085-08-7)
- Methyl 3-nitro-4-(trifluoromethyl)benzoate (CAS 126541-81-9)
- ethyl 7-(difluoromethyl)-5-oxo-4,5-dihydropyrazolo[1,5-a]pyrimidine-2-carboxylate (CAS 938001-08-2)
- 3-O-Acetyl-16alpha-hydroxytrametenolic acid (CAS 168293-13-8)
- 6-Phenyl-5-hexenoic Acid (CAS 16424-56-9)
- 3-(Aminomethyl)-2,3-dimethylpentan-2-ol (CAS 1535999-32-6)
- ETHYL 2-(BENZO[B]THIOPHEN-3-YL)-2-(DIMETHYLAMINO)ACETATE (CAS 1007885-53-1)
- Tadalafil Impurity 25 (CAS CATO-C4X-108725)
- Semaglutide impurity 235 (CAS CATO-C4X-2226235)
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