rac-(3R,4R)-4-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride CAS 1909288-72-7
| CAS No. | 1909288-72-7 |
| Molecular Formula | C6H8F3NO2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of rac-(3R,4R)-4-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride (C6H8F3NO2HCl) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
rac-(3R,4R)-4-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride (CAS 1909288-72-7), molecular formula C6H8F3NO2HCl and molecular weight 219.59 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures rac-(3R,4R)-4-(trifluoromethyl)pyrrolidine-3-carboxylic acid hydrochloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H8F3NO2 HCl |
| Molecular Weight | 219.59 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 1-(3-Bromo-4-methylphenyl)pyrrolidine (CAS 1215917-98-8)
- α-Pyrrolidinovalerophenone HCl (α-PVP HCl) (CAS 5485-65-4)
- (5-Amino-1-ethyl-1H-pyrazol-3-yl)(pyrrolidin-1-yl)methanone (CAS 1856093-06-5)
- 4-Allyl-1,3-dimethylpiperidin-4-ol (CAS 695204-42-3)
- TL 13-27 (CAS 2250025-90-0)
- Methyl 4-(4-heptylphenyl)-2-methyl-5-oxo-4,5-dihydro-1H-indeno[1,2-b]pyridine-3-carboxylate (CAS 439110-72-2)
- (2E)-3-{4-[(ethylamino)sulfonyl]phenyl}acrylic acid (CAS 926219-87-6)
- (E)-icos-3-ene (CAS 74685-33-9)
- 4-{[3-(trifluoromethyl)phenyl]methoxy}aniline (CAS 231278-67-4)
- (Des-Thr?)-Glucagon trifluoroacetate salt (CAS 1802078-27-8)
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