5-(chlorosulfonyl)-3-fluoro-2-methylbenzoic acid CAS 1909326-68-6
| CAS No. | 1909326-68-6 |
| Molecular Formula | C8H6ClFO4S |
| Molecular Weight | 252.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5-(chlorosulfonyl)-3-fluoro-2-methylbenzoic acid (CAS 1909326-68-6) is a high-purity analytical reference standard with the molecular formula C8H6ClFO4S and a molecular weight of 252.65 g/mol.
The molecular framework of 5-(chlorosulfonyl)-3-fluoro-2-methylbenzoic acid (C8H6ClFO4S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 5-(chlorosulfonyl)-3-fluoro-2-methylbenzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6ClFO4S |
| Molecular Weight | 252.65 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
Related chlorosulfonyl Standards
- 5-(chlorosulfonyl)-4-fluoro-2-methylbenzoic acid (CAS 1026030-54-5)
- Methyl 4-(chlorosulfonyl)-2-fluorobenzoate (CAS 1063733-16-3)
- Methyl 3-(chlorosulfonyl)-4-fluorobenzoate (CAS 1099660-67-9)
- Methyl 3-(chlorosulfonyl)-5-fluorobenzoate (CAS 1155909-75-3)
- Methyl 2-(Chlorosulfonyl)-4-fluorobenzoate (CAS 1156254-63-5)
- methyl 2-(chlorosulfonyl)-6-fluorobenzoate (CAS 120257-01-4)
- Methyl 4-(chlorosulfonyl)-3-fluorobenzoate (CAS 1219687-20-3)
- 3-(Chlorosulfonyl)-4-fluoro-5-methylbenzoic acid (CAS 1242339-88-3)
Recommended Standards
- Methyl 3-(5-Chloro-2-hydroxyphenyl)-1H-pyrazole-5-carboxylate (CAS 187225-50-9)
- Methyl 4-chloro-3-(fluorosulfonyl)benzoate (CAS 1955499-69-0)
- 4-Chloro-6-methoxyquinazolin-7-yl acetate (CAS 179688-03-0)
- Methyl 4-chloro-2-(fluorosulfonyl)benzoate (CAS 1955505-45-9)
- 7-[4-(Morpholine-4-sulfonyl)phenoxy]-2,4-bis(trifluoromethyl)-1,8-naphthyridine (CAS 338412-25-2)
- 1-(4-methylphenyl)propan-1-amine hydrochloride (CAS 1185341-34-7)
- (2-(Trifluoromethyl)pyrimidin-5-yl)methanesulfonyl chloride (CAS 1196155-63-1)
- 6-Hydroxybenzofuran-5-carbaldehyde (CAS 20073-22-7)
- Methyl 4-(2-(2-((4-chlorophenyl)carbamothioyl)hydrazinyl)-2-oxoethoxy)benzoate (CAS 1024147-43-0)
- 2-Acetamido-6-acetylpyridine-4-sulfonyl chloride (CAS 1393571-06-6)
- 1228070-75-4 2571AD 5-Amino-1-(isopropylcarbamoyl-methyl)-1H-[1,2,3]triazole-4-carboxylic acid amide C8H14N6O2 (CAS 1228070-75-4)
- Methyl (1R,2S)-1-amino-2-vinylcyclopropane-1-carboxylate (CAS 681260-04-8)
- 5-Iodo-1H-pyrazole-3-carbonitrile (CAS 1533442-33-9)
- Semaglutide impurity 103 (CAS 1446013-07-5)
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