2-Amino-6-(trifluoromethyl)nicotinamide CAS 191478-53-2
| CAS No. | 191478-53-2 |
| Molecular Formula | C7H6F3N3O |
| Molecular Weight | 205.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-Amino-6-(trifluoromethyl)nicotinamide (CAS 191478-53-2), molecular formula C7H6F3N3O and molecular weight 205.14 g/mol, is a CATO reference standard with documented purity and traceability.
2-Amino-6-(trifluoromethyl)nicotinamide (C7H6F3N3O) contains an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C7H6F3N3O |
| Molecular Weight | 205.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2011 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Amino Standards
- (2-Amino-4,6-difluorophenyl)dimethylphosphine oxide (CAS 2798867-81-7)
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- (6-Amino-2,3-difluorophenyl)dimethylphosphine oxide (CAS 2798867-79-3)
- 3-Amino-6-(trifluoromethyl)picolinamide (CAS 946594-91-8)
- (S)-2-Amino-2-(3,4,5-trifluorophenyl)acetic acid (CAS 1022990-86-8)
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- 2-Amino-2-(2,4,5-trifluorophenyl)acetic acid (CAS 1043500-64-6)
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Recommended Standards
- (4-Bromobutyl)cyclopentane (CAS 18914-30-2)
- N-Hydroxy-6-(trifluoromethyl)picolinimidamide (CAS 1923811-65-7)
- N-Hydroxy-5-(trifluoromethyl)picolinimidamide (CAS 175277-44-8)
- (1-Bromopropan-2-yl)cyclohexane (CAS 910891-58-6)
- 2-((4-Methoxybenzyl)oxy)isoindoline-1,3-dione (CAS 2014-61-1)
- Methyl 5-bromo-3-cyano-2-methoxybenzoate (CAS 1807081-09-9)
- 3,3-Dimethyl-2-oxoindoline-6-carbaldehyde (CAS 1831887-17-2)
- 2-Chloro-5,6,7,8-tetrahydroquinoline-3-carbonitrile (CAS 65242-27-5)
- 1-Methyl-3-phenyl-1H-pyrazole-5-carbaldehyde (CAS 864068-96-2)
- 1-Methyl-N-(5-((phenylthio)methyl)-1,3,4-oxadiazol-2-yl)-1H-pyrazole-3-carboxamide (CAS 1172814-93-5)
- 6-(Butylsulfonyl)-1,2,4-triazine-3,5(2H,4H)-dione (CAS 90008-87-0)
- 5-Methyl-1-(p-tolyl)-1H-pyrazol-3(2H)-one (CAS 67915-96-2)
- N-Methyl-1H-imidazole-1-carboxamide (CAS 72002-25-6)
- Semaglutide Impurity 192 (CAS CATO-C4X-2226192)
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