4-Amino-2-chloro-5-nitropyrimidine CAS 1920-66-7
| CAS No. | 1920-66-7 |
| Molecular Formula | C4H3ClN4O2 |
| Molecular Weight | 174.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Amino-2-chloro-5-nitropyrimidine.
4-Amino-2-chloro-5-nitropyrimidine (CAS 1920-66-7) is a high-purity analytical reference standard with the molecular formula C4H3ClN4O2 and a molecular weight of 174.55 g/mol.
4-Amino-2-chloro-5-nitropyrimidine (C4H3ClN4O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-Amino-2-chloro-5-nitropyrimidine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C4H3ClN4O2 |
| Molecular Weight | 174.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
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Recommended Standards
- 4-Chloro-5-nitropyrimidin-2-amine (CAS 160948-35-6)
- 2-Chloro-4-nitropyrimidin-5-amine (CAS 618397-67-4)
- 2-Methyl-4,4,4-trifluorobutyryl chloride (CAS 136564-78-8)
- 3-(2-chloro-1,1,2-trifluoroethoxy)prop-1-ene 380-44-9 Allyl 2-chloro-1,1,2-trifluoroethyl ether (CAS 380-44-9)
- 6-Fluorobenzo[b]thiophen-2-amine (CAS 1293987-81-1)
- 5-Methoxypyrazin-2(1H)-one (CAS 134510-06-8)
- 6-bromo-2-chloroimidazo[1,2-a]pyridine (CAS 851916-84-2)
- 3-Ethyl-2-methylhexa-1,3-diene (CAS 61142-36-7)
- N-allyl-5-bromopyrimidin-2-amine (CAS 886365-97-5)
- 1-(4-Methoxyphenyl)-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)urea (CAS 874298-01-8)
- (S)-phenyl(piperidin-4-yl)methanol (CAS 957202-21-0)
- 4-(Aminomethyl)-3-cyano-6-(difluoromethyl)picolinic acid (CAS 1805577-80-3)
- 1H-Imidazolium,3,3'-methylenebis[1-(4-carboxy-2-methylphenyl)-,chloride(1:2) (CAS 1414865-04-5)
- Semaglutide impurity 38 (CAS CATO-C4X-222638)
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