Lopinavir EP Impurity A CAS 192726-05-9
| CAS No. | 192726-05-9 |
| Molecular Formula | C27H38N4O3 |
| Molecular Weight | 466.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Lopinavir EP Impurity A (CAS 192726-05-9) is a certified pharmaceutical impurity reference standard with the molecular formula C27H38N4O3 and a molecular weight of 466.62 g/mol.
Based on its molecular formula C27H38N4O3, Lopinavir EP Impurity A contains a steroid core, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 466.62 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H38N4O3 |
| Molecular Weight | 466.62 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2012 |
| Nitrogen Atoms | 4 |
Related Lopinavir Standards
- Lopinavir EP Impurity H (CAS CATO-C4X-16828)
- Lopinavir EP Impurity F (CAS CATO-C4X-16826)
- Lopinavir EP Impurity E (CAS 192725-49-8)
- Lopinavir Impurity 35 (CAS 3023702-69-1)
- Lopinavir EP Impurity G (CAS CATO-C4X-16827)
- Lopinavir EP Impurity B (CAS CATO-C4X-16822)
- Lopinavir Related Compound C (CAS 2125942-48-3)
- Lopinavir EP Impurity L (CAS CATO-C4X-168212)
Recommended Standards
- N-(5-phenyl-4-pivaloyl-5-(vinylsulfonamidomethyl)-4,5-dihydro-1,3,4-thiadiazol-2-yl)pivalamide (CAS 546111-92-6)
- 1-(((4-Benzhydrylpiperazin-1-yl)sulfonyl)methyl)-7,7-dimethylbicyclo[2.2.1]Heptan-2-one (CAS 626215-92-7)
- (H-Cys-Leu-OH)2 (G-1820.0250) (CAS 21141-85-5)
- 21658-11-7 Lyso SM (dihydro) (d18:0) (CAS 21658-11-7)
- Dotinurad Impurity 195 (CAS 50910-59-3 (free base))
- Gadoteridol Impurity 10 (CAS CATO-C4X-225710)
- Brexpiprazole Impurity 172 (CAS CATO-C4X-1131172)
- 5-Isobutylpyridin-3-ol (CAS 117765-11-4)
- 1-Allylpiperidine-2,5-dione (CAS 564484-67-9)
- Methyl 16-oxohexadecanoate (CAS 45247-78-7)
- 3-chloro-1-benzofuran-7-carbaldehyde (CAS 1428415-53-5)
- 5-Methylpyrazine-2-carboximidamide hydrochloride (CAS 1171036-44-4)
- 2,3-Difluoro-6-isopropoxybenzaldehyde (CAS 949026-89-5)
- Fas C- Terminal Tripeptide (CAS 189109-90-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com