Anastrozole Impurity 12 CAS 19294-04-3
| CAS No. | 19294-04-3 |
| Molecular Formula | C9H10Br2 |
| Molecular Weight | 277.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Anastrozole Impurity 12.
Anastrozole Impurity 12 (CAS 19294-04-3) is a certified pharmaceutical impurity reference standard with the molecular formula C9H10Br2 and a molecular weight of 277.98 g/mol.
The molecular framework of Anastrozole Impurity 12 (C9H10Br2) is characterized by bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Anastrozole Impurity 12 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H10Br2 |
| Molecular Weight | 277.98 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Br-containing |
Related Anastrozole Standards
- Anastrozole EP Impurity A (CAS 1215780-15-6)
- Anastrozole Impurity 32 (CAS CATO-C4X-123932)
- Anastrozole Impurity 38 (CAS CATO-C4X-123938)
- Anastrozole Impurity 31 (CAS CATO-C4X-123931)
- Anastrozole (CAS 120511-73-1)
- Anastrozole EP Impurity G (CAS 120511-92-4)
- Anastrozole EP Impurity I (CAS 120511-91-3)
- Anastrozole Impurity 2 (CAS 120512-36-9)
Recommended Standards
- 5-Bromo-2-(bromomethyl)-1,3-dimethylbenzene (CAS 2090975-80-5)
- 2,4-Dibromo-1,3,5-trimethylbenzene (CAS 6942-99-0)
- 4-Bromo-2,5-dimethylbenzyl bromide (CAS 88111-73-3)
- 2,4-Dichloro-1-fluoro-3-nitro-5-(trifluoromethyl)benzene (CAS 1221272-80-5)
- Crotamiton Impurity N6 (CAS CATO-CP143086)
- Terbutaline Impurity 44 (CAS 2095852-55-2)
- Rimegepant Impurity 143 (CAS CATO-C4X-2487143)
- Acid Red 26 (CAS 3761-53-3)
- Labetalol Impurity 69 (CAS CATO-C4X-246669)
- 2-n-(4-Bromophenyl)pyridine-2,3-diamine (CAS 78750-67-1)
- Methyl 3-(2-oxopropyl)benzoate (CAS 74998-19-9)
- N-Methyl-2-(piperazin-1-yl)nicotinamide (CAS 902837-15-4)
- 1-Isobutyl-1H-tetrazole-5-thiol (CAS 7624-34-2)
- Urotensin II-Related Peptide (human, mouse, rat) (CAS 342878-90-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com