4-Amino-2,5-difluoro-6-(fluoromethyl)-3-iodobenzonitrile CAS 1935029-52-9
| CAS No. | 1935029-52-9 |
| Molecular Formula | C8H4F3IN2 |
| Molecular Weight | 312.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-Amino-2,5-difluoro-6-(fluoromethyl)-3-iodobenzonitrile (C8H4F3IN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 4-Amino-2,5-difluoro-6-(fluoromethyl)-3-iodobenzonitrile (CAS 1935029-52-9), a certified reference material (molecular formula C8H4F3IN2, MW 312.03 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-Amino-2,5-difluoro-6-(fluoromethyl)-3-iodobenzonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4F3IN2 |
| Molecular Weight | 312.03 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 2-Amino-3-iodo-5-(trifluoromethyl)benzonitrile (CAS 1221792-71-7)
- 4-AMino-3-iodo-5-trifluoromethyl-benzonitrile (CAS 62584-29-6)
- 4-Amino-5-iodo-2-(trifluoromethyl)benzonitrile (CAS 852569-35-8)
- Ethyl 2-amino-5-bromo-4-(trifluoromethyl)benzoate (CAS 1131587-99-9)
- (S)-3-Amino-3-(4,5-dibromofuran-2-yl)propanamide (CAS 1344960-25-3)
- (R)-3-Amino-3-(4,5-dibromofuran-2-yl)propanamide (CAS 1562434-15-4)
- 2-Amino-4-iodobenzyl bromide (CAS 1260761-43-0)
- Ethyl 8-amino-6-bromo-4-oxo-4H-chromene-2-carboxylate (CAS 156904-82-4)
Recommended Standards
- 2-(Difluoromethyl)-3-fluoro-6-iodopyridine-5-acetonitrile (CAS 1807134-33-3)
- 4-Iodo-2-(trifluoromethyl)-1H-benzo[d]imidazole (CAS 1935284-08-4)
- 2-(Difluoromethyl)-3-fluoro-6-iodopyridine-4-acetonitrile (CAS 1807099-00-8)
- 3-(3-Iodophenyl)-3-(trifluoromethyl)-3H-diazirine (CAS 81340-56-9)
- (2R,3S)-2-(Fmoc-amino)-3-hydroxy-4-methylpentanoic Acid (CAS 1217833-77-6)
- 4-Chloro-8-methoxy-3-methylquinoline (CAS 39593-11-8)
- 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)octanoic acid (CAS 197384-29-5)
- (3-Chlorobenzyl)glycine hydrochloride (CAS 72761-90-1)
- Epimestrol (CAS 7004-98-0)
- 4-Bromo-N,N-bis(4-butoxyphenyl)aniline (CAS 666711-17-7)
- 1-(Methoxymethyl)-2-azaspiro[3.3]heptane (CAS 1873950-47-0)
- 1-(1-Chloropropan-2-yl)pyrrolidine (CAS 58414-76-9)
- 5-Amino-3-(4-tetrahydropyranyl)isoxazole (CAS 1188908-57-7)
- Insulin degludec (CAS 844439-96-9)
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