2-Chloro-5-(difluoromethoxy)-3-nitropyridine CAS 1935596-08-9
| CAS No. | 1935596-08-9 |
| Molecular Formula | C6H3ClF2N2O3 |
| Molecular Weight | 224.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-5-(difluoromethoxy)-3-nitropyridine.
2-Chloro-5-(difluoromethoxy)-3-nitropyridine (CAS 1935596-08-9), molecular formula C6H3ClF2N2O3 and molecular weight 224.55 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-Chloro-5-(difluoromethoxy)-3-nitropyridine (C6H3ClF2N2O3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 224.55 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 2-Chloro-5-(difluoromethoxy)-3-nitropyridine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H3ClF2N2O3 |
| Molecular Weight | 224.55 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-5-(difluoromethyl)-3-nitropyridin-2-ol (CAS 1804672-16-9)
- 6-Chloro-5-(difluoromethyl)-4-nitropyridin-3-ol (CAS 1805055-27-9)
- 4-Chloro-2-(difluoromethyl)-5-nitropyridin-3-ol (CAS 1805057-15-1)
- 6-Chloro-2-(difluoromethyl)-5-nitropyridin-3-ol (CAS 1805386-28-0)
- 6-Chloro-3-(difluoromethyl)-5-nitropyridin-2-ol (CAS 1806872-35-4)
- 3-Chloro-2-(difluoromethoxy)-5-nitropyridine (CAS 1832583-47-7)
- 2-(3-Chloro-4-fluorophenyl)-2,2-difluoroacetic acid (CAS 1027514-19-7)
- 2-Chloro-4-(trifluoromethoxy)benzaldehyde (CAS 1079351-20-4)
Recommended Standards
- 5-Chloro-2-(trifluoromethoxy)benzaldehyde (CAS 1092461-15-8)
- 3-Chloro-4-(trifluoromethyl)benzoic Acid (CAS 115754-20-6)
- Methyl 3-chloro-2,4,5-trifluorobenzoate (CAS 1214375-02-6)
- 4-Chloro-2-(trifluoromethoxy)benzaldehyde (CAS 1261442-48-1)
- N-Isopropyl-2-(piperazin-1-yl)propanamide (CAS 86906-58-3)
- 1-Benzyl-6-chloro-2-oxo-1,2-dihydroquinoline-3-carbonitrile (CAS 89479-58-3)
- (2R,3R,4R,5R)-2-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-hydroxy-5-((phosphonooxy)methyl)tetrahydrofuran-3-yl acetate (CAS 90290-63-4)
- Letrozole Impurity 7 (CAS 1644566-39-1)
- 3-(2-Chloroacetyl)-1-(propan-2-yl)urea (CAS 7248-86-4)
- 4-Chloro-5,7-difluoro-3-iodoquinoline (CAS 1431363-51-7)
- 2-(Ethylamino)-N-methylpyrimidine-5-carboxamide (CAS 1862914-34-8)
- Formoterol Impurity 71 (CAS 71250-20-9)
- 2,2-Dimethyl-4-(2-methoxyphenyl)-4-oxobutyric acid (CAS 898766-64-8)
- Peptide YY (3-36) (canine, mouse, porcine, rat) trifluoroacetate salt (CAS 126339-09-1)
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