6-Bromo-4-(trifluoromethyl)pyrimidine-2(1H)-thione CAS 1936659-99-2
| CAS No. | 1936659-99-2 |
| Molecular Formula | C5H2BrF3N2S |
| Molecular Weight | 259.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
6-Bromo-4-(trifluoromethyl)pyrimidine-2(1H)-thione (CAS 1936659-99-2), molecular formula C5H2BrF3N2S and molecular weight 259.05 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Bromo-4-(trifluoromethyl)pyrimidine-2(1H)-thione (C5H2BrF3N2S) is characterized by a nitrile group, sulfur-containing functionality, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 6-Bromo-4-(trifluoromethyl)pyrimidine-2(1H)-thione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H2BrF3N2S |
| Molecular Weight | 259.05 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 1-(2-Bromophenyl)-3-methyl-1h-pyrazol-5-amine (CAS 1155573-56-0)
- Clonidine EP Impurity C (CAS 608-31-1)
- 1-(chloromethyl)-4,7-dimethyl[1,2,4]triazolo[4,3-a]quinazolin-5(4H)-one (CAS 1114824-01-9)
- 4-Bromo-N-(4-fluorophenyl)benzamide (CAS 346723-41-9)
- Edoxaban Impurity N82 (CAS 165948-23-2)
- 5-Methoxy-1H-indol-3-ol (CAS 909031-92-1)
- F5097NG7JT 24751-69-7 Nucleocidin Nulceocidin Adenosine, 4'-C-fluoro-, 5'-sulfamate T-3018 Antibiotic T-3018 4'-C-Fluoroadenosine 5'-sulfamate 4'-Fluoro-5'-O-sulfamoyladenosine 9-(4-Fluoro-5-O-sulfamoylpentofuranosyl)adenine NSC 521007 UNII-F5097NG7JT (CAS 24751-69-7)
- Semaglutide impurity 198 (CAS CATO-C4X-2226198)
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