Ethyl 4-chloro-8-iodoquinoline-3-carboxylate CAS 193975-33-6
| CAS No. | 193975-33-6 |
| Molecular Formula | C12H9ClINO2 |
| Molecular Weight | 361.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 4-chloro-8-iodoquinoline-3-carboxylate.
Ethyl 4-chloro-8-iodoquinoline-3-carboxylate (CAS 193975-33-6), molecular formula C12H9ClINO2 and molecular weight 361.56 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 4-chloro-8-iodoquinoline-3-carboxylate (C12H9ClINO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H9ClINO2 |
| Molecular Weight | 361.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2012 |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
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- 4-Aminobenzotriazole (CAS 18076-61-4)
- 5-Chloro-7-(3-nitrophenyl)quinolin-8-ol (CAS 648896-52-0)
- 4-Cyano-6-(difluoromethyl)-2-hydroxypyridine-3-sulfonyl chloride (CAS 1805185-77-6)
- (S)-2-Amino-2-(2,4-dichlorophenyl)acetic acid (CAS 936352-56-6)
- 2-Formylfuran-3-carboxylic acid (CAS 14757-79-0)
- Methyl (2e)-3-(pyrimidin-5-yl)prop-2-enoate (CAS 866621-24-1)
- Tert-butyl 4-(4-bromopyridin-2-yl)-4-(hydroxymethyl)piperidine-1-carboxylate (CAS 1394066-48-8)
- 8-Fluoro-2,7-dimethyl-5-nitroquinoline (CAS 1420800-10-7)
- Palmitoyl Hexapeptide-12 TFA salt (CAS 171263-26-6(Free Base))
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