2,4-difluoro-3-hydroxybenzoic acid methyl ester CAS 194804-80-3
| CAS No. | 194804-80-3 |
| Molecular Formula | C8H6F2O3 |
| Molecular Weight | 188.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2,4-difluoro-3-hydroxybenzoic acid methyl ester is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 188.13 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
2,4-difluoro-3-hydroxybenzoic acid methyl ester (CAS 194804-80-3) is a high-purity analytical reference standard with the molecular formula C8H6F2O3 and a molecular weight of 188.13 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6F2O3 |
| Molecular Weight | 188.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2012 |
| Halogen Content | F-containing |
Related difluoro Standards
- 2-(2,5-Difluoro-4-hydroxyphenyl)acetic acid (CAS 1042703-29-6)
- 2-(3,5-Difluoro-4-hydroxyphenyl)acetic acid (CAS 1042703-32-1)
- 2,5-Difluoro-4-methoxybenzoic acid (CAS 1060739-01-6)
- 2,4-DIFLUORO-3-METHYL-5-NITROBENZENAMINE (CAS 112822-77-2)
- (2,4-Difluoro-5-nitrophenyl)methanamine (CAS 1158049-24-1)
- 3,5-Difluoro-4-(hydroxymethyl)benzoic acid (CAS 1211596-29-0)
- Methyl 3,6-difluoro-2-hydroxybenzoate (CAS 1214324-50-1)
- 2,6-Difluoro-3-hydroxy-benzoic acid methyl ester (CAS 1214332-41-8)
Recommended Standards
- 2,5-Difluoro-4-(hydroxymethyl)benzoic acid (CAS 1895356-29-2)
- Methyl 2,6-Difluoro-4-hydroxybenzoate (CAS 194938-88-0)
- 2,3-Difluoro-4-(hydroxymethyl)benzoic acid (CAS 1891434-71-1)
- (2,4-Difluorophenoxy)acetic acid (CAS 399-44-0)
- Fluralaner-d5-15N (CAS CATO-C4X-21802)
- 3-Cyclopropanecarbonyl-5-fluoropyridine (CAS 1248370-09-3)
- N-Cyclopropyl-6-(trifluoromethyl)-2-pyridinamine (CAS 944580-74-9)
- 4-({Prop-2-yn-1-yl)-3,4-dihydrothieno[3,2-f][1,4]thiazepin-5(2H)-one (CAS 477845-64-0)
- 2-Methyl-2-(1H-pyrazol-1-yl)propan-1-amine dihydrochloride (CAS 2031269-46-0)
- MRL-871 (CAS 1392809-08-3)
- 4-Phenoxybenzenethiol (CAS 38778-05-1)
- Proxalutamide (CAS 1398046-21-3)
- 6-Bromo-2-chloro-8-fluoroquinoline (CAS 1215767-81-9)
- Semaglutide Impurity 183 (CAS 159541-28-3)
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