3',5'-Bis(trifluoromethyl)biphenyl-4-carboxylic acid CAS 195457-74-0
| CAS No. | 195457-74-0 |
| Molecular Formula | C15H8F6O2 |
| Molecular Weight | 334.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 334.21 g/mol gives 3',5'-Bis(trifluoromethyl)biphenyl-4-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3',5'-Bis(trifluoromethyl)biphenyl-4-carboxylic acid (CAS 195457-74-0), molecular formula C15H8F6O2 and molecular weight 334.21 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system, 3',5'-Bis(trifluoromethyl)biphenyl-4-carboxylic acid is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 334.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3',5'-Bis(trifluoromethyl)biphenyl-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H8F6O2 |
| Molecular Weight | 334.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2012 |
| Halogen Content | F-containing |
Related Bis Standards
- 4',6-Bis(trifluoromethyl)-[1,1'-biphenyl]-2-carboxylic acid (CAS 1261733-06-5)
- 2,4'-Bis(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid (CAS 1261788-46-8)
- 3',5'-Bis(trifluoromethyl)biphenyl-3-carboxylic acid (CAS 177733-57-2)
- 6-(Trifluoromethyl)-N-[3-(trifluoromethyl)phenyl]pyridine-3-carboxamide (CAS 1092346-26-3)
- 3-(6-Oxo-4-(trifluoromethyl)pyrimidin-1(6H)-yl)-5-(trifluoromethyl)picolinonitrile (CAS 1823183-17-0)
- 2-(3-(2-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)benzoic acid (CAS 1707567-31-4)
- 2-(3-(4-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)benzoic acid (CAS 1708400-81-0)
- 2-(3-(3-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)benzoic acid (CAS 1710344-35-6)
Recommended Standards
- Benzyl 4-Bromophenethylcarbamate (CAS 191170-76-0)
- (4-(Trifluoromethoxy)phenyl)(4-(trifluoromethyl)phenyl)methanone (CAS 34367-37-8)
- Benzyl (R)-(1-(3-bromophenyl)ethyl)carbamate (CAS 1845807-71-7)
- 2-(Benzyloxy)-N-(3-bromobenzyl)acetamide (CAS 2007044-68-8)
- (3-Chloro-4-((4-ethylpiperazin-1-yl)methyl)phenyl)boronic acid (CAS 1704074-25-8)
- 4-Bromo-N,N-diethylpyridin-2-amine (CAS 1142194-28-2)
- 4-(Aminomethyl)-5-bromo-2-(methylthio)pyrimidine (CAS 1823402-38-5)
- 4-Chloro-5-ethyl-6-(methylthio)pyrimidine (CAS 1340052-38-1)
- 2-(5-Methyl-2-benzoxazolyl)phenol (CAS 35875-76-4)
- 3-Amino-3-(2,3-dihydrobenzo[b][1,4]dioxin-2-yl)propan-1-ol (CAS 1420788-66-4)
- (4-(Benzyloxy)phenyl)(4-phenylpiperazin-1-yl)methanethione (CAS 327074-64-6)
- 2-Methoxyquinoline-4-carbaldehyde (CAS 893760-88-8)
- 4'-Formyl-3-methoxy-[1,1'-biphenyl]-4-carboxylic acid (CAS 1261958-93-3)
- Tirzepatide (CAS 2023788-19-2)
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