4-Chloro-2-methyl-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinazoline CAS 1956325-86-2
| CAS No. | 1956325-86-2 |
| Molecular Formula | C10H10ClF3N2 |
| Molecular Weight | 250.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-2-methyl-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinazoline (CAS 1956325-86-2) is a high-purity analytical reference standard with the molecular formula C10H10ClF3N2 and a molecular weight of 250.65 g/mol.
Structurally, 4-Chloro-2-methyl-6-(trifluoromethyl)-5,6,7,8-tetrahydroquinazoline (C10H10ClF3N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 250.65 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10ClF3N2 |
| Molecular Weight | 250.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-Chloro-6-(pyrrolidin-1-yl)-4-(trifluoromethyl)pyridine (CAS 1053657-79-6)
- 4'-Chloro-5-fluoro-[1,1'-biphenyl]-2-carboxylic acid (CAS 1179253-24-7)
- 4’-Chloro-4-fluorobiphenyl-3-carboxylic Acid (CAS 1179618-11-1)
- 3'-Chloro-4'-fluoro-[1,1'-biphenyl]-2-carboxylic acid (CAS 1181295-51-1)
- 6-Chloro-4'-fluoro-[1,1'-biphenyl]-3-carboxylic acid (CAS 1181566-97-1)
- 4'-Chloro-6-fluoro-[1,1'-biphenyl]-3-carboxylic acid (CAS 1181639-60-0)
- 4-Chloro-3'-fluoro-[1,1'-biphenyl]-3-carboxylic acid (CAS 1183702-65-9)
- (R)-2-Chloro-3-(pyrrolidin-2-yl)-6-(trifluoromethyl)pyridine (CAS 1213469-00-1)
Recommended Standards
- 3'-Chloro-4'-fluoro-[1,1'-biphenyl]-4-carboxylic acid (CAS 195457-73-9)
- 4-Chloro-2-methyl-7-(trifluoromethyl)-5,6,7,8-tetrahydroquinazoline (CAS 1956330-89-4)
- 4-(Trifluoromethyl)thiophene-3-sulfonyl chloride (CAS 1855675-37-4)
- (E)-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N,N-dimethylethen-1-amine (CAS 338978-12-4)
- 2,3,5,6-Tetrafluoro-4-(trifluoromethyl)benzenesulfonyl chloride (CAS 40586-68-3)
- 7-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolin-3-amine (CAS 1382851-41-3)
- 2-Fluoro-6-methoxyisonicotinaldehyde (CAS 1227563-69-0)
- 4,6-Bis(4-methoxyphenyl)-2-((4-methylbenzyl)thio)nicotinonitrile (CAS 332114-66-6)
- 2-(2-Bromophenyl)-4-(4-methylbenzylidene)oxazol-5(4H)-one (CAS 84156-17-2)
- (1R,4R)-4-amino-2,2-difluorocyclopentane-1-carboxylic acid hydrochloride (CAS 2496497-75-5)
- 5-Amino-2-(4-chlorophenyl)pyridazin-3(2H)-one (CAS 84956-67-2)
- N-(8-azabicyclo[3.2.1]Octan-3-yl)thiazol-2-amine (CAS 1250956-33-2)
- 4-Methoxy-N-(4-methoxyphenyl)-N-(4-nitrophenyl)aniline (CAS 20440-91-9)
- (His32,Leu34)-Neuropeptide Y (32-36) (CAS 168916-68-5)
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