2-(2-Chloro-5-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxylic acid CAS 1956334-29-4
| CAS No. | 1956334-29-4 |
| Molecular Formula | C14H8ClFN2O2 |
| Molecular Weight | 290.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(2-Chloro-5-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxylic acid (C14H8ClFN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
2-(2-Chloro-5-fluorophenyl)imidazo[1,2-a]pyridine-3-carboxylic acid (CAS 1956334-29-4), molecular formula C14H8ClFN2O2 and molecular weight 290.68 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H8ClFN2O2 |
| Molecular Weight | 290.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
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- 637753-85-6 (2Z)-2-(2-Chloro-6-fluorobenzylidene)-6-hydroxy-1-benzofuran-3(2H)-one MFCD04181737 (CAS 637753-85-6)
- tert-Butyl (5-chloro-4-fluoro-2-nitrophenyl)carbamate (CAS 473547-10-3)
- rac-(2S,3R)-2-(pyridin-3-yl)oxolan-3-amine dihydrochloride (CAS 2059917-90-5)
- 2-(3-chloro-2-fluorophenyl)-2-methylpropan-1-amine hydrochloride (CAS 1797306-72-9)
- 2-(1-(2-Fluorophenyl)ethyl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid (CAS 1443292-38-3)
- Ethyl 1-(3-bromophenyl)cyclopentane-1-carboxylate (CAS 885068-62-2)
- 2,4-Dibromo-6-fluorophenol (CAS 576-86-3)
- 3-(3-bromopropyl)-1,3-oxazolidin-2-one (CAS 42351-29-1)
- P-(1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctyl)phosphonic Acid 4-Methylbenzeneamine Salt (CAS 1263361-03-0)
- 4,8-Dichloro-6-methyl-2-phenylquinoline (CAS 1153165-79-7)
- Adrenochrome Impurity 4 (CAS 99069-59-7)
- Neuropeptide Y (free acid) (human, rat) trifluoroacetate salt (CAS 99575-89-0)
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