8-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine dihydrochloride CAS 1965308-96-6
| CAS No. | 1965308-96-6 |
| Molecular Formula | C9H11FN2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 202.66 g/mol gives 8-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine dihydrochloride distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
8-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine dihydrochloride (CAS 1965308-96-6), molecular formula C9H11FN2HCl and molecular weight 202.66 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 8-Fluoro-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepine dihydrochloride (C9H11FN2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H11FN2 2*HCl |
| Molecular Weight | 202.66 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
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- Ethyl 4-fluoro-3-ethoxybenzoate (CAS 1000207-63-5)
- 6-fluoro-4-iodo-1H-benzo[d]imidazole (CAS 1000308-33-7)
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- 3-Fluoro-2-nitrobenzoic Acid (CAS 1000339-51-4)
Recommended Standards
- (1-Ethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)boronic acid (CAS 1289141-90-7)
- 6-prop-1-ynyl-2,3-dihydro-1H-quinolin-4-one (CAS 2493748-88-0)
- n-(M-tolyl)tetrahydro-2h-thiopyran-3-amine (CAS 1340051-23-1)
- 2-(2-Hydroxy-1-phenylethyl)isoindolin-1-one (CAS 199868-84-3)
- 3-((Tert-butoxycarbonyl)amino)-2-(4-methoxybenzyl)propanoic acid (CAS 683218-95-3)
- 3-Amino-N-(3-methylisoxazol-5-yl)propanamide (CAS 1352505-84-0)
- Bis(3-((benzylidene)amino)propyl)amine (CAS 80525-57-1)
- tert-Butyl (5-aminobenzo[d]thiazol-2-yl)carbamate (CAS 894427-09-9)
- 3-Chloro-N-(3-cyanophenyl)-2,2-dimethylpropanamide (CAS 341965-80-8)
- Semaglutide Impurity 2 (CAS CATO-C4X-22262)
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