Ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate CAS 197299-16-4

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate.

Ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate (CAS 197299-16-4) is a high-purity analytical reference standard with the molecular formula C13H18O4 and a molecular weight of 238.28 g/mol.

Ethyl 2-ethoxy-3-(4-hydroxyphenyl)propanoate (C13H18O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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