4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine CAS 1978-59-2
| CAS No. | 1978-59-2 |
| Molecular Formula | C11H12FN |
| Molecular Weight | 177.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine.
4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine (CAS 1978-59-2), molecular formula C11H12FN and molecular weight 177.22 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, 4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 177.22 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(4-Fluorophenyl)-1,2,3,6-tetrahydropyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H12FN |
| Molecular Weight | 177.22 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluorophenyl Standards
- 4-(2-Fluorophenyl)-1,2,3,6-tetrahydropyridine (CAS 143682-23-9)
- 3-(4-Fluorophenyl)bicyclo[1.1.1]pentan-1-amine (CAS 1810070-22-4)
- 3-(2-Fluorophenyl)-3-methylbutanenitrile (CAS 1936094-14-2)
- 4-(3-Fluorophenyl)-1,2,3,6-tetrahydropyridine (CAS 1978-60-5)
- 3-(4-Fluorophenyl)-N,N-dimethylprop-2-yn-1-amine (CAS 860003-19-6)
- 6-(4-Fluorophenyl)-2,3,4,5-tetrahydropyridine (CAS 509953-48-4)
- 1-(3-Fluorophenyl)piperazine (CAS 104396-10-3)
- 3-(3-Fluorophenyl)-1H-pyrazol-5-amine (CAS 1028842-99-0)
Recommended Standards
- 1-Ethanesulfonylpyrrolidin-3-one (CAS 1936626-41-3)
- 4-(3-Fluorobicyclo[1.1.1]Pentan-1-yl)aniline (CAS 1936606-29-9)
- (2R)-2-Amino-3-((E)-prop-1-en-1-ylsulfinyl)propanoic acid (CAS 434322-95-9)
- 7-Fluoro-1,1-dimethyl-1H-inden-4-amine (CAS 1936166-14-1)
- Sodium Ethanesulfinate (CAS 20035-08-9)
- Isometheptene Impurity E (CAS 4436-89-9)
- 3-(2-Methylbenzyl)-1H-pyrazole (CAS 1260676-05-8)
- 3-((2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)picolinonitrile (CAS 1421262-92-1)
- 2-Methoxy-1-(4-methoxyphenyl)-N-methylethan-1-amine (CAS 1247242-66-5)
- 1-(3-Chloro-2-methylpropyl)-2-fluoro-benzene (CAS 101975-64-8)
- 2,2-Dimethyl-3a,4,9,9a-tetrahydronaphtho[2,3-D][1,3]dioxol-5-ol (CAS 344314-18-7)
- 2-Hydroxyamino-3-methyl-3H-imidazo[4,5-f]quinoline (CAS 77314-23-9)
- 2-(4-Fluoro-3-methylphenyl)morpholine (CAS 1267436-33-8)
- Neuropeptide W-23 (rat) (CAS 383415-89-2)
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