4-Amino-3-chloropyridine CAS 19798-77-7
| CAS No. | 19798-77-7 |
| Molecular Formula | C5H5ClN2 |
| Molecular Weight | 128.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Amino-3-chloropyridine (CAS 19798-77-7), molecular formula C5H5ClN2 and molecular weight 128.56 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Amino-3-chloropyridine (C5H5ClN2) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Amino-3-chloropyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H5ClN2 |
| Molecular Weight | 128.56 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1962 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 5-Amino-2-chloropyridine (CAS 5350-93-6)
- 4-Amino-2-chloropyridine (CAS 14432-12-3)
- 3-Amino-2-chloropyridine (CAS 6298-19-7)
- (2-Amino-1-cyclopropylethyl)dimethylamine (CAS 1092301-70-6)
- N-(2-amino-2-methylpropyl)cyclopropanamine (CAS 1247812-41-4)
- 2-Amino-5,6-dimethylpyridine (CAS 57963-08-3)
- 4-Amino-1,2-dimethylpiperidine (CAS 89850-92-0)
- (E)-(4-Amino-4-oxobut-1-en-1-yl)boronic acid (CAS 195379-23-8)
Recommended Standards
- Edoxaban Impurity 7 (CAS 1072-98-6)
- Edoxaban impurity 101 (CAS 39620-04-7)
- Phenol, 3-chloro-, homopolymer (CAS 25231-12-3)
- Edoxaban Impurity 110 (CAS 45644-21-1)
- (3-Methyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetonitrile (CAS 1211484-07-9)
- N-((4-(Dimethylamino)pyrimidin-2-yl)methyl)thiophene-2-carboxamide (CAS 1797078-61-5)
- 2,5-Dichloro-6-(trifluoromethyl)pyrimidin-4-amine (CAS 84737-30-4)
- 3-{[2-(2,4-dichlorophenyl)-2-oxoethyl]sulfanyl}-5-methyl-1,2-thiazole-4-carbonitrile (CAS 343372-95-2)
- Tetrapropylammonium hexafluorophosphate(V) (CAS 12110-21-3)
- Ethyl 1,2,3,4-Tetrahydroquinoline-2-carboxylate (CAS 4620-34-2)
- (2Z)-3-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-2-(4-chlorophenyl)prop-2-enenitrile (CAS 320420-51-7)
- 4-(4-Fluorophenyl)piperidin-2-one (CAS 1891169-00-8)
- 2-(3-(3-Methyl-1,2,4-oxadiazol-5-yl)azetidin-1-yl)acetic acid hydrochloride (CAS 1426290-57-4)
- Galanin Message Associated Peptide (44-59) amide (CAS 125455-59-6)
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