Parecoxib Impurity 67 CAS 198471-83-9
| CAS No. | 198471-83-9 |
| Molecular Formula | C19H18N2O5S |
| Molecular Weight | 386.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Parecoxib Impurity 67 (C19H18N2O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Parecoxib Impurity 67 (CAS 198471-83-9, C19H18N2O5S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Parecoxib Impurity 67 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H18N2O5S |
| Molecular Weight | 386.42 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2013 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Parecoxib Standards
- Parecoxib Impurity 39 (CAS CATO-C4X-159139)
- Parecoxib Impurity 41 (CAS 198470-82-5)
- Parecoxib Impurity 42 (CAS CATO-C4X-159142)
- Parecoxib Impurity 43 (CAS 1373038-59-5)
- Parecoxib Impurity 53 (CAS CATO-C4X-159153)
- Parecoxib Impurity 54 (CAS CATO-C4X-159154)
- Parecoxib Impurity 55 (CAS CATO-C4X-159155)
- Parecoxib Impurity 56 (CAS CATO-C4X-159156)
Recommended Standards
- Pioglitazone impurity 47 (CAS 146062-48-8)
- Eldecalcitol Impurity 62 (CAS CATO-C4X-214062)
- N-(3-(N-(Furan-2-ylmethyl)sulfamoyl)phenyl)-4-methoxybenzamide (CAS 522625-85-0)
- Eldecalcitol Impurity 63 (CAS CATO-C4X-214063)
- Empagliflozin Impurity 67 (CAS CATO-C4X-106567)
- Perospirone impurity 48 (CAS CATO-C4X-245848)
- Diazoxide impurity 8 (CAS CATO-C4X-19528)
- 7-Bromo-2,3-dimethylimidazo[1,2-a]pyridine (CAS 1173656-67-1)
- 1-Bromo-4-chloro-2-methyl-5-nitrobenzene (CAS 10289-13-1)
- methyl 4-bromo-3-methylthieno[2,3-c]pyridine-2-carboxylate (CAS 870244-28-3)
- Methyl Indole-4-carboxylate (CAS 39830-66-5)
- 2-Fluoro-4,5-dimethoxy-benzamide (CAS 1260658-21-6)
- 1-(6-Bromopyridin-2-yl)-2,2,2-trifluoroethan-1-amine (CAS 886364-60-9)
- D-[γ-Glu](Side Chain)-Semaglutide (CAS CATO-C4X-2226254)
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