(E)-3-(4-(Trifluoromethoxy)phenyl)acrylic acid CAS 199679-35-1
| CAS No. | 199679-35-1 |
| Molecular Formula | C10H7F3O3 |
| Molecular Weight | 232.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(E)-3-(4-(Trifluoromethoxy)phenyl)acrylic acid (CAS 199679-35-1), molecular formula C10H7F3O3 and molecular weight 232.16 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C10H7F3O3, (E)-3-(4-(Trifluoromethoxy)phenyl)acrylic acid contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 232.16 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (E)-3-(4-(Trifluoromethoxy)phenyl)acrylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7F3O3 |
| Molecular Weight | 232.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2014 |
| Halogen Content | F-containing |
Related E Standards
- trans-3-(Trifluoromethoxy)cinnamic acid (CAS 168833-80-5)
- (E)-3-[2-(Trifluoromethoxy)phenyl]acrylic Acid (CAS 399579-92-1)
- 2-(4-(Trifluoromethoxy)phenyl)malonaldehyde (CAS 493036-48-9)
- 3-(2-(Trifluoromethoxy)phenyl)acrylic acid (CAS 399580-48-4)
- 4-(Trifluoromethoxy)cinnamic Acid (CAS 783-13-1)
- 6-(Trifluoromethoxy)chroman-4-one (CAS 874774-49-9)
- 7-(Trifluoromethoxy)chroman-4-one (CAS 340825-26-5)
- 8-(Trifluoromethoxy)chroman-4-one (CAS 276697-79-1)
Recommended Standards
- 8-(2,2,2-Trifluoroethoxy)-[1,2,4]triazolo[1,5-a]pyridin-2-amine (CAS 1951444-85-1)
- Methyl 4-formyl-3-(trifluoromethyl)benzoate (CAS 1823806-70-7)
- 1-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)-2,2,2-trifluoroethan-1-one (CAS 2091613-32-8)
- 2-(Aminomethyl)-5-(trifluoromethoxy)benzo[d]oxazole (CAS 1807067-46-4)
- 3,5-Dichloro-2,6-difluoro-4-pyridinol (CAS 2693-61-0)
- 2-Fluoro-4-(3-oxomorpholino)benzaldehyde (CAS 1260674-82-5)
- 3-(Aminocarbonyl)-5-bromobenzenesulfonyl chloride (CAS 1485868-72-1)
- Ethyl 5-nitropentanoate (CAS 13154-39-7)
- 2-(4-Bromophenyl)-6-fluoro-3-methylquinoline-4-carboxylic acid (CAS 130507-37-8)
- 4-(dichloromethylene)morpholin-4-ium (CAS 790600-30-5)
- (4-Cyclopropyl-6-methylpyrimidin-5-yl)boronic acid (CAS 1817776-86-5)
- 2,5-Diethylfuran-3-carboxylic acid (CAS 758723-72-7)
- 1-(6-Hydroxyindolin-1-yl)ethanone (CAS 4770-34-7)
- Peptide Impurity (CAS CATO-CPTD788810)
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